Neuroblastoma (NB) evolves from primitive neural crest cells, and the sympathetic nerve chain and adrenal medulla are the most common primary sites. Different ages, tumor sites and different degrees of tissue differentiation make their biological characteristics and clinical manifestations very different. Some can naturally regress or transform into benign tumors, but other patients are very difficult to treat and have a poor prognosis. In the past 30 years, the prognosis of infantile or early NB has improved significantly, but the prognosis of older patients with advanced disease is still very poor. There are many factors that can affect the prognosis of NB, and age and stage are still the most important factors.