Myelopathy caused by systemic lupus erythematosus (SLE) is the manifestation of SLE lesions in the spinal cord. SLE is a specific autoimmune disease involving multiple factors (genetics, sex hormones, environment, infection, drugs, and immune response), which can affect multiple systems, so symptoms of multi-organ damage appear. At the beginning of the disease, there are often irregular fevers, with skin damage being the most common, butterfly-shaped erythema on the cheeks and bridge of the nose, and rashes may also occur on the neck or trunk; in addition, joint pain and lymphadenopathy are often associated. Damage to the central nervous system caused by SLE is the main cause of death, which is statistically between 20% and 60%, and some reports can be as high as 75% (Johnson, 1968). Recurrent convulsions are the most common, followed by cranial nerve disorders, mental disorders, cerebrovascular accidents, increased intracranial pressure and meningitis, involuntary movements, and peripheral nerve damage such as Raynaud's phenomenon.