Mizoribine structure
Mizoribine
Mizoribine(NSC 289637; HE 69; β-Bredinin) is an immunosuppressive agents (IC50=100 uM) that inhibit the proliferation of lymphocytes selectively, via inhibition of IMPDH.IC50 Value:Target: IMPDHin vitro: Unlike azathioprine, Mizoribine is not taken up by nucleic acids in the cell. Instead, after phosphorylation MZR-5 -monophosphate inhibits GMP synthesis by the antagonistic blocking of IMPDH (Ki = 10(-8)M) and GMP- synthetase (Ki =10(-5) M) [1]. Pretreatment of cells with MZR partially,
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PHARMACOSTECH CO.,LTD.
South Korea
South Korea
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South Korea
North China Pharmaceutical Huasheng Co., Ltd.
China
China
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Founded in:
1995-05-04 -
Country:
China -
Address:
No. 8 Yangzi Road, Shijiazhuang Economic and Technological Development Zone -
Tax NO.:
91130182601702614Y -
Registered Funds:
237.4751 million yuan -
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Nanjing Hicin Pharmaceutical Co., Ltd.
China
China
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API Active
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Founded in:
2003-01-15 -
Country:
China -
Address:
No. 1 Hengfa Road, Nanjing Economic and Technological Development Zone -
Tax NO.:
913201927453675877 -
Registered Funds:
120 million yuan -
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