Voriconazole structure
Voriconazole
Cyrstalline SolidVoriconazole was introduced in the US for the treatment of acute invasive aspergillosis,
candidosis and other emerging fungal infections seen in immuno compromised patients. It
can be synthesized in 3 steps by reaction of readily available 6-( 1 -bromoethyl)-4-chloro-5
fluoropyrimidine with I-(2,4-difluorophenyl)-2-(1,2,4-triazol-I-yl) ethanone in the presence
of zinc metal. The resulting racemic mixture was submitted to a reductive dechlorination
step followed by resoluti
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