Tolcapone structure
Tolcapone
Yellow SolidTolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone (Tasmar), is a yellow, odorless, nonhygroscopic,crystalline compound (pKa＝4.78). Tolcapone israpidly absorbed after oral administration. Tolcapone ishighly bound to plasma albumin (＞98%), and its distributionis therefore restricted. Tolcapone has low first-pass metabolism.It is almost completely metabolized in the liver before excretion, and 60% is excreted by the kidney.
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PIRAMAL PHARMA LTD
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COHANCE LIFESCIENCES LTD
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Hunan Zhongqi Pharmaceutical Co., Ltd. Yueyang Branch
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