(-)-Pimecrolimus structure
(-)-Pimecrolimus
Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.Target: OthersPimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function [1]. Pimecrolimus prevents the release of cytokines and pro-inflammatory mediators from mast cells. Pimecrolimus binds to macrophilin-12, the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase. The pimecrolimus-macrophilin complex
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CURIA Italy SRL
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BrightGene Pharmaceutical Co., Ltd.
China
China
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CHENGDU YACHT BIOTECHNOLOGY CO LTD
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Sichuan Novals Pharmaceuticals Co., Ltd.
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No. 16, Middle Section of Industrial Avenue, Qinglong Town, Pengshan District, Meishan City, Sichuan Province -
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