Bosentan structure
Bosentan
Pale Yellow to Off-White SolidBosentan was introduced in the US as a twice-daily oral treatment for pulmonary
arterial hypertension. It can be synthesized in five steps via condensation of diethyl (2-
methoxyphenoxy)malonate with pyrimidine-2-carboxamidine to give the precursor of the
symmetrical central dichloropyrimidine ring which is then successively treated with the
potassium salt of 4-tert-butylbenzenesulfonamide and the sodium salt of ethylene gycol.
Bosentan is the first endothelin
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ALIVUS LIFE SCIENCES LTD
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MATRIX PHARMACORP PRIVATE LTD
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ALEMBIC PHARMACEUTICALS LTD
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Beijing Ansenbo Pharmaceutical Technology Co., Ltd.
China
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1207, Floor 12, Building 2, Yard 10, Wangjing Street, Chaoyang District, Beijing -
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Actelion Pharmaceuticals Trading (Shanghai) Co., Ltd.
China
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2014-03-24 -
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Jiangsu Tasly DIYI Pharmaceutical Co., Ltd.
China
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No. 168, Chaoyang West Road, Qingpu Industrial Park, Huai'an City -
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91320800139432975C -
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China Sinopharm International Corporation
China
China
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1989-02-18 -
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No. 4 Huixin East Street, Chaoyang District, Beijing -
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91110000100009467D -
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Aurovitas PHARMA Taizhou Co., Ltd.
China
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No. 196, Xiangtai Road, Taizhou Pharmaceutical Hi-tech Zone -
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