Sevelamer carbonate structure
Sevelamer carbonate
Sevelamer carbonate (SC) is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. SC has been found to have the same safety and efficacy profile as Sevelamer HCl in HD patients.Sevelamer carbonate(Renvela) is a nonaluminum, non-calcium-basedphosphorus binder that traps phosphorus in the bowel through ion exchange and hydrogen binding. This drug replaced sevelamer hydrochloride(Renagel) and has an advantage of not generating an acid load, as its precursor, sevelamer hydrochloride, did. It also has the advantage of lowering LDL cholesterol due to gut binding of bile acids.
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Waterstone Pharmaceuticals (HuBei) Co., Ltd.
China
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Nanjing Hencer Pharmaceutical Co., Ltd.
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1995-12-27 -
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Shandong Xinhua Pharmaceutical Company Limited
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SHANDONG XINHUA PHARMACEUTICAL CO LTD
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CTX LIFE SCIENCES PVT LTD
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CHEMO IBERICA SA MADRID
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