Olmesartan medoxomil structure
Olmesartan medoxomil
White to off-white crystalline powderOlmesartan medoxomil was launched in the US as benicar@, an orallyadministered treatment for hypertension. This ester prodrug of olmesartan can besynthesized in 8 steps from diaminomaleonitrile by successive reactions withtrialkylorthopropanoate to access 2-propyl-imidazole-45dicarbonitrile, conversion of thetwo nitrile functions to the corresponding ethyl esters, followed by methylmagnesiumbromide addition to give the corresponding 4-(1-hydroxyalk
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