Tianjin Tianjiao Pharmaceutical Co., Ltd.

A highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, anti-itching and vasoconstrictive effects. It increases the reactivity of beta receptors to catecholamine, increases CAMP production by activating adenylate cyclase, and reduces CAMP destruction by inhibiting phosphoethylesterase, resulting in an increase in cAMP concentration in cells and inhibiting the release of histamine. Its effect in inhibiting the proliferation of granulomas in rats and mice is similar to that of dexamethasone, and it can inhibit formaldehyde-induced heel swelling in mice and rats. It has a significant weight-loss effect on the thymus and spleen. It reduces the number of T lymphocytes, monocytes, and eosinophils, inhibits lymphocyte proliferation and cytokine production, inhibits macrophage differentiation and phagocytic activity, inhibits neutrophil adhesion, reduces vascular endothelial cell permeability, inhibits fibroblast proliferation and collagen synthesis, and inhibits sebaceous gland cell activity. It has an anti-mitotic effect, reduces PNA transcription, thereby reducing DNA synthesis, affecting DNA repair, and thinning the epidermis, especially the greatest effect on collagen synthesis. By binding to the cytoplasmic corticosteroid receptors, it activates the expression of lytic genes, induces nuclear DNA cleavage in lymphocytes, and directly kills lymphocytes, causing death.

It has anti-inflammatory, anti-itching and vasoconstrictive effects; it increases the responsiveness of beta receptors to catecholamines, increases CAMP production by activating adenylate cyclase, and reduces CAMP destruction by inhibiting phosphoethylesterase, resulting in an increase in cAMP concentration in cells and inhibiting the release of histamine; it inhibits the proliferation of granulomas in rats and mice; it reduces the number of T lymphocytes, monocytes, and eosinophils, inhibits lymphocyte proliferation and cytokine production, inhibits macrophage differentiation and phagocytic activity, inhibits neutrophil adhesion, reduces vascular endothelial cell permeability, inhibits fibroblast proliferation and collagen synthesis, and inhibits sebaceous gland cell activity; it has anti-mitotic effects, reduces PNA transcription and thus reduces DNA synthesis, affects DNA repair, and thins the epidermis, especially the synthesis of collagen; it activates the expression of lytic genes by binding to the cytoplasmic corticosteroid receptors, induces nuclear DNA lysis in lymphocytes, and directly kills lymphocytes.

This product is a highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, anti-pruritic and vasoconstrictive effects. Its anti-inflammatory and antipruritic mechanism is to increase the reactivity of beta receptors to catecholamine, increase CAMP production by activating adenylate cyclase, and inhibit phosphoethylesterase to reduce CAMP destruction, resulting in an increase in the annual concentration of cAMP in cells and inhibiting the release of histamine. The effect of this product in inhibiting the proliferation of granulomas in rats and mice is similar to that of dexamethasone. Using the formaldehyde-induced heel swelling method in mice and rats, this product and dexamethasone both have significant inhibitory effects, while a 5-fold higher dose of hydrocortisone has no inhibitory effect. This product has a significant weight-reducing effect on the thymus and spleen. It reduces the number of T lymphocytes, monocytes, and eosinophils, inhibits lymphocyte proliferation and cytokine production, inhibits macrophage differentiation and phagocytic activity, inhibits neutrophil adhesion, reduces the permeability of vascular endothelial cells, inhibits fibroblast proliferation and collagen synthesis, and inhibits sebaceous gland cell activity. This product has an anti-mitotic effect. It reduces the transcription of PNA, thereby reducing the synthesis of DNA and also affects the repair of DNA, resulting in thinning of the epidermis, especially affecting the synthesis of collagen. By binding to the corticosteroid receptors in the cytoplasm, a series of reactions occur, activating the expression of lytic genes in the cells; it induces the cleavage of nuclear DNA in lymphocytes and directly kills lymphocytes.

This product is a highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, anti-pruritic and vasoconstrictive effects. Its anti-inflammatory and antipruritic mechanism is to increase the reactivity of beta receptors to catecholamine, increase CAMP production by activating adenylate cyclase, and inhibit phosphoethylesterase to reduce CAMP destruction, resulting in an increase in cAMP concentration in cells and inhibiting the release of histamine. This product has a similar effect as dexamethasone in inhibiting the proliferation of granulomas in rats and mice. It has a significant weight-loss effect on the thymus and spleen, reduces the number of T lymphocytes, monocytes, and eosinophils, inhibits lymphocyte proliferation and cytokine production, inhibits macrophage differentiation and phagocytic activity, inhibits neutrophil adhesion, reduces vascular endothelial cell permeability, inhibits fibroblast proliferation and collagen synthesis, and inhibits sebaceous gland cell activity. This product has an anti-mitotic effect. It reduces the transcription of PNA, thereby reducing DNA synthesis, and also affects DNA repair, resulting in thinning of the epidermis, especially the greatest effect on collagen synthesis. This product binds to the corticosteroid receptors in the cytoplasm, causing a series of reactions and activating the expression of lytic genes in the cells; it induces nuclear DNA cleavage in lymphocytes and directly kills lymphocytes.

This product has anti-anaerobic effect, and its mechanism of action is to hinder bacterial metabolism and promote its death.