Suzhou Pharmaceutical Factory

This product is a semi-synthetic aminoglycoside antibiotic. It has strong antibacterial activity against aerobic Gram-negative bacteria, and its antibacterial spectrum is similar to that of gentamicin. It has good antibacterial effects on Escherichia coli, Pseudomonas aeruginosa, indole-negative and -positive Proteus, Klebsiella, Acinetobacter, Citrobacter, and some strains of Serratia and Enterobacter. It also has good antibacterial effects on Mycobacterium tuberculosis, atypical mycobacteria and Staphylococcus aureus (enzyme-producing and non-enzyme-producing strains). Other Gram-positive bacteria (including fecal streptococci), anaerobic bacteria, Rickettsia, fungi and viruses are not sensitive to this product. This product is stable to aminoglycoside acetyltransferase AAC (3), so it can produce this enzyme. Strains resistant to kanamycin, gentamicin, tobramycin and sisomicin are sensitive to this product. This product can often achieve synergistic effects when used in combination with beta-lactams. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. Animal test data indicate that this product has lower ototoxicity than gentamicin and tobramycin, and lower nephrotoxicity than gentamicin.

This product is a semi-synthetic aminoglycoside antibiotic. It has strong antibacterial activity against aerobic Gram-negative bacteria, and its antibacterial spectrum is similar to that of gentamicin. It has good antibacterial effects on Escherichia coli, Pseudomonas aeruginosa, indole-negative and -positive Proteus, Klebsiella, Acinetobacter, Citrobacter, and some strains of Serratia and Enterobacter. It also has good antibacterial effects on Mycobacterium tuberculosis, atypical mycobacteria and Staphylococcus aureus (enzyme-producing and non-enzyme-producing strains). Other Gram-positive bacteria (including fecal streptococci), anaerobic bacteria, Rickettsia, fungi and viruses are not sensitive to this product. This product is stable to aminoglycoside acetyltransferase AAC (3), so it can produce this enzyme. Strains resistant to kanamycin, gentamicin, tobramycin and sisomicin are sensitive to this product. This product can often achieve synergistic effects when used in combination with beta-lactams. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. Animal test data indicate that this product has lower ototoxicity than gentamicin and tobramycin, and lower nephrotoxicity than gentamicin.

This product is a phenothiazine antipsychotic, and its mechanism of action is mainly related to its blocking of dopamine receptors (DA2) in the mesolimbic system and mesocortical pathways. It has a blocking effect on dopamine (DA1) receptors, 5-hydroxytryptamine receptors, M-type acetylcholine receptors, and α-adrenaline receptors. At low doses, it can inhibit dopamine receptors in the medulla oblongata emetic chemoreceptor area, and at high doses, it can directly inhibit the vomiting center, producing a powerful antiemetic effect. It inhibits the body temperature regulation center, lowering the body temperature, which can change with changes in the external environment. It blocks the action of peripheral α-adrenaline receptors, causing blood vessels to dilate, causing a drop in blood pressure, and also has a certain effect on the endocrine system.

This product is an acetanilide antipyretic analgesic. It inhibits the prostaglandin synthase in the hypothalamic temperature regulation center, reduces the synthesis and release of prostaglandin PGE1, causes peripheral vasodilation and sweating, and achieves an antipyretic effect. Its antipyretic effect is similar to that of aspirin; it inhibits the synthesis and release of prostaglandin PGE1, bradykinin and histamine, increases the pain threshold and has an analgesic effect. It is a peripheral analgesic, weaker than aspirin, and is only effective for mild and moderate pain. This product has no obvious anti-inflammatory effect.

This product is an acetanilide antipyretic analgesic. It inhibits the prostaglandin synthase in the hypothalamic temperature regulation center, reduces the synthesis and release of prostaglandin PGE1, causes peripheral vasodilation and sweating, and achieves an antipyretic effect. Its antipyretic effect is similar to that of aspirin; it inhibits the synthesis and release of prostaglandin PGE1, bradykinin and histamine, increases the pain threshold and has an analgesic effect. It is a peripheral analgesic, weaker than aspirin, and is only effective for mild and moderate pain. This product has no obvious anti-inflammatory effect.