Anti-platelet aggregation, depolymerization of aggregated platelets, dilation of arterioles, improvement of microcirculation, increase of cerebral blood flow, anti-thrombosis and thrombolysis

This product is an alpha adrenergic receptor blocker that acts on both alpha 1 and alpha 2 receptors, dilating blood vessels and thus reducing peripheral vascular resistance. The mechanism of action for treating male erectile dysfunction may be to dilate the penile artery vessels, increase the blood flow in the cavernous body, thereby improving the penile erectile function, increasing the hardness of the penis, and prolonging the duration of erection.

The effect on water and electrolyte excretion is basically the same as furosemide, and its diuretic effect is 20 to 60 times that of furosemide. It mainly inhibits the active reabsorption of NaCl by the thick wall segment of the ascending limb of the renal tubular loop of Henle, and also inhibits the reabsorption of Na+ in the proximal tubule, but has no effect on the distal tubule, so the potassium excretion effect is less than furosemide. It can inhibit the activity of prostaglandin degrading enzymes, increase the content of prostaglandin E2, and thus have a vasodilatory effect. Dilation of renal blood vessels, reduction of renal vascular resistance, and increase of renal blood flow, especially deep renal cortical blood flow, are of great significance in the diuretic effect of bumetanide, and are also the theoretical basis for its use in the prevention of acute renal failure. In addition, unlike other diuretics, loop diuretics increase the flow of renal tubular fluid while the glomerular filtration rate does not decrease, which may be related to the reduction of chloride flowing through the macula densa, thereby weakening or blocking the glomerular-tubular balance. Bumetanide can dilate the pulmonary capacitance veins and reduce the permeability of pulmonary capillaries. Its diuretic effect can reduce the amount of blood returning to the heart and the left ventricular end-diastolic pressure, which is helpful for the treatment of acute left heart failure. Since bumetanide can reduce the permeability of pulmonary capillaries, it provides a theoretical basis for its treatment of adult respiratory distress syndrome.

It is a multi-component macrolide antibiotic produced by Streptomyces, which has strong antibacterial effects on Gram-positive bacteria and mycoplasma, and also has antibacterial effects on some Gram-negative bacteria such as Neisseria meningitidis and Neisseria gonorrhoeae. It works by acting on the 50S subunit of bacterial ribosomes, hindering the synthesis of bacterial proteins, and is an antibacterial drug during the growth period.

It is a multi-component macrolide antibiotic produced by Streptomyces, which has strong antibacterial effects on Gram-positive bacteria and mycoplasma, and also has antibacterial effects on some Gram-negative bacteria such as Neisseria meningitidis and Neisseria gonorrhoeae. It works by acting on the 50S subunit of bacterial ribosomes, hindering the synthesis of bacterial proteins, and is an antibacterial drug during the growth period.

It can restore the imbalance between the excitation and inhibition processes of the cerebral cortex, and produce central inhibitory effects such as sedation, hypnosis and analgesia