Ganshu Minhai Pharmacy Co., Ltd.

This product is a broad-spectrum antibacterial agent with bactericidal effect at high concentrations. In addition to common Gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria, most Rickettsia, Mycoplasma, Chlamydia, atypical mycobacteria and spirochetes are also sensitive to this product. This product is better than Gram-positive bacteria for Gram-negative bacteria, but Enterococcus is resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, etc. are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant gonococci are also resistant to tetracycline. This product has good antibacterial effect on Gram-negative bacteria such as Vibrio, Yersinia pestis, Brucella, Campylobacter, Yersinia, etc., has no antibacterial activity against Pseudomonas aeruginosa, and has certain antibacterial effect on some anaerobic bacteria.

It has the function of increasing the activity of digestive enzymes; it can increase the activity of pepsin and pancreatic lipase; it has the function of affecting intestinal motility; it can increase the propulsion rate of charcoal in the small intestine of mice; it can antagonize the inhibitory effect of atropine sulfate on small intestinal motility.

It has the function of increasing the activity of digestive enzymes; it can increase the activity of pepsin and pancreatic lipase; it has the function of affecting intestinal motility; it can increase the propulsion rate of charcoal in the small intestine of mice; it can antagonize the inhibitory effect of atropine sulfate on small intestinal motility.

It has the function of increasing the activity of digestive enzymes; it can increase the activity of pepsin and pancreatic lipase; it has the function of affecting intestinal motility; it can increase the propulsion rate of charcoal in the small intestine of mice; it can antagonize the inhibitory effect of atropine sulfate on small intestinal motility.

Trimethoprim (TMP) is an antibacterial agent, a lipophilic weak base, and its chemical structure belongs to the pyrimethamine class. It has antibacterial activity against Escherichia coli, Klebsiella, Proteus mirabilis, Salmonella, and Shigella, but has no obvious antibacterial effect on Streptococcus pneumoniae, Neisseria gonorrhoeae, and Neisseria meningitidis, and has no effect on Pseudomonas aeruginosa. The mechanism of action of this product is to interfere with bacterial folic acid metabolism. It mainly selectively inhibits the activity of bacterial dihydrofolate reductase, so that dihydrofolate cannot be reduced to tetrahydrofolate, and synthetic folic acid is the main component of nucleic acid biosynthesis. Therefore, this product prevents the synthesis of bacterial nucleic acids and proteins, and the binding of this product to bacterial dihydrofolate reductase is 50,000 to 60,000 times tighter than that to mammalian enzymes. The combination of this product and sulfonamides can double block the bacterial folic acid synthesis metabolism, have a synergistic effect, enhance the antibacterial activity of sulfonamides, and convert the antibacterial effect into a bactericidal effect, reducing the production of drug-resistant strains.