Prednisone Acetate Tablets

Prednisolone acetate. Chemical name: 17α, 21-dihydroxypregnane-1,4-diene-3,11,20-trione 21-acetate Molecular weight: C23H28O6

This product is white tablets.

Oral administration, generally 5~10mg (1~2 tablets) at a time, 10~60mg (2~12 tablets) a day. Increase or decrease as necessary, determined by the doctor. 1. For autoimmune diseases such as systemic lupus erythematosus, nephrotic syndrome, ulcerative colitis, autoimmune hemolytic anemia, etc., 40-60mg can be given daily, and the dosage can be gradually reduced after the condition stabilizes. 2. For allergic diseases such as drug-induced dermatitis, urticaria, bronchial asthma, etc., prednisone can be given at 20-40mg daily, and the dosage can be reduced after the symptoms are alleviated, reducing by 5mg every 1-2 days. 3. To prevent organ transplant rejection, generally start taking 100mg orally daily 1-2 days before surgery, change to 60mg daily one week after surgery, and then gradually reduce the dosage. 4. For the treatment of acute leukemia and malignant tumors, take 60-80mg orally daily.

Large doses of this product can easily cause diabetes, peptic ulcers and symptoms similar to Cushing's syndrome, and have a strong inhibitory effect on the hypothalamus-pituitary-adrenal axis. Concurrent infection is the main adverse reaction.

Patients with a history of allergy to this product and adrenal cortex hormones are prohibited from using it. Patients with hypertension, thrombosis, gastric and duodenal ulcers, mental illness, electrolyte metabolism abnormalities, myocardial infarction, visceral surgery, glaucoma, etc. are generally not suitable for use. In special cases, weigh the pros and cons and pay attention to the possibility of worsening of the condition.

Precautions for children: Children should be very cautious when using adrenocortical hormones for a long time, because hormones can inhibit the growth and development of children. If long-term use is necessary, short-acting (such as cortisone) or medium-acting preparations (such as prednisone) should be used, and long-acting preparations (such as dexamethasone) should be avoided. Oral medium-acting preparations every other day can reduce the inhibitory effect on growth. Children or adolescents who use glucocorticoids for a long time must be closely observed, as the risk of osteoporosis, avascular necrosis of the femoral head, glaucoma, and cataracts in children is increased. In addition to the general age and weight, the dosage of hormones for children should be determined according to the severity of the disease and the child's response to treatment. For the treatment of children with adrenocortical insufficiency, the dosage of hormones should be determined according to the body surface area, otherwise overdose is likely to occur, especially during pregnancy and lactation. Precautions: Use by pregnant women can increase the incidence of placental insufficiency, neonatal weight loss, or stillbirth. Animal experiments have teratogenic effects, so the pros and cons should be weighed. If a nursing mother receives a large dose of the drug, she should not breastfeed to prevent the drug from being excreted through breast milk, which may cause adverse reactions such as growth inhibition and adrenal function suppression in infants. Precautions for the elderly: The use of glucocorticoids is prone to high blood pressure, and elderly patients, especially postmenopausal women, are prone to osteoporosis.

1. Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. Long-term use with anticholinergics (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by it. 7. When used in combination with hypoglycemic drugs such as insulin, the dose of hypoglycemic drugs should be adjusted appropriately because it can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase its metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with it, the dose of the latter should be adjusted appropriately. 9. With contraceptives

seal.

5mg*100s

24 months