Nifedipine sustained-release tablets (Ⅰ)
Function and Efficacy
Nifedipine is a dihydropyridine calcium antagonist that selectively inhibits the transmembrane transport of calcium ions into myocardial cells and smooth muscle cells, and inhibits the release of calcium ions from intracellular pools without changing the plasma calcium ion concentration. Pharmacology: This product can simultaneously relax the coronary arteries in the normal blood supply area and the ischemic area, antagonize spontaneous or ergonovine-induced coronary artery spasm, increase the delivery of myocardial oxygen in patients with coronary artery spasm, and relieve and prevent coronary artery spasm. It can also inhibit myocardial contraction, reduce myocardial metabolism, and reduce myocardial oxygen consumption. On the other hand, it can relax peripheral resistance vessels, reduce peripheral resistance, reduce systolic and diastolic blood pressure, and reduce cardiac afterload. This product can delay the sinus node function and atrioventricular conduction of isolated hearts; electrophysiological studies of whole animals and humans have not found that this product has the effect of delaying atrioventricular conduction, prolonging the recovery time of the sinus node, and slowing down the sinus node rate. Toxicology (carcinogenicity, mutagenicity and reproductive toxicity) No carcinogenic effect. No mutagenicity. Large doses can reduce the fertility of female mice, cause teratogenesis, and induce abortion (increased drug absorption rate in fetal mice, increased fetal mortality, and decreased survival rate of newborn mice). Pregnant monkeys taking 2/3 to 2 times the maximum human dose can cause small placenta and chorionic dysplasia; giving rats 3 times the maximum human dose can cause prolonged pregnancy.
Ingredients
Main ingredients: Contains nifedipine. Molecular formula: C17H18N2O6 Molecular weight: 346.34
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| NifedipineIngredients |
Dihydropyridine calcium antagonists can selectively inhibit the transmembrane transport of calcium ions into myocardial cells and smooth muscle cells, and inhibit the release of calcium ions from intracellular pools without changing the plasma calcium ion concentration. It can simultaneously relax the coronary arteries in the normal blood supply area and the ischemic area, antagonize spontaneous or ergonovine-induced coronary artery spasm, increase the delivery of myocardial oxygen to patients with coronary artery spasm, and relieve and prevent coronary artery spasm. It can also inhibit myocardial contraction, reduce myocardial metabolism, and reduce myocardial oxygen consumption. On the other hand, it can relax peripheral resistance vessels, reduce peripheral resistance, reduce systolic and diastolic blood pressure, and reduce cardiac afterload. It can delay the sinoatrial node function and atrioventricular conduction of isolated hearts; electrophysiological studies on whole animals and humans have not found that this product has the effect of delaying atrioventricular conduction, prolonging the recovery time of the sinoatrial node, and slowing down the sinoatrial node rate. More |
21829-25-4 | 75 |
Appearance
Film-coated tablets appear yellow after removing the film coating.
Indication
Various types of hypertension and angina pectoris.
Usage and Dosage
Oral: 10-20 mg once, twice a day. Maximum dose: 40 mg once, 0.12 g a day.
Adverse Reactions
1 Liver: Occasionally, jaundice and elevated glutamate oxaloacetate aminotransferase and glutamate pyruvate aminotransferase may occur. 2 Circulatory system: Occasionally, chest pain, headache, flushing, dizziness, palpitations, decreased blood pressure, lower limb edema may occur. 3 Allergies: Occasionally, allergic symptoms such as measles and itching may occur. 4 Digestive system: Occasionally, abdominal pain, nausea, loss of appetite, constipation may occur. 5 Oral cavity: Gum hypertrophy may occur. 6 Metabolic abnormalities: Occasionally, symptoms of high blood sugar may occur.
Precautions
It is forbidden to use by pregnant women and children.
Special Population Medication
Precautions for children: Children are prohibited from using. Precautions for pregnancy and lactation: Pregnant women are prohibited. Precautions for the elderly: See [Usage and Dosage] or follow the doctor's advice.
Drug Interactions
Not yet clear.
Storage
Keep away from light and sealed.
Packaging Specification
10mg
Validity Period
Tentative 24 months
Manufacturer
Di'ao Group Chengdu Pharmaceutical Co., Ltd.
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Founded in:
1997-07-31 -
Address:
No. 518, Herui Road, Chengdu Hi-tech Zone -
Tax NO.:
91510100201913965Q -
Registered Funds:
71.01 million yuan -
Website:
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Email: