Azithromycin Granules
Function and Efficacy
Azithromycin inhibits bacterial protein synthesis by hindering the bacterial transpeptidation process. In vitro tests have shown that azithromycin has antibacterial effects on a variety of common pathogens in clinical practice, including: Gram-positive aerobic bacteria: Staphylococcus aureus, Streptococcus pyogenes (Group A B hemolytic streptococci), Pneumococcus, α-hemolytic streptococci (grass viridans streptococci) and other streptococci, diphtheria (rod-shaped) bacilli. This product shows cross-resistance to erythromycin-resistant Gram-positive bacteria, including fecal streptococci (enterococci) and methicillin-resistant Staphylococcus aureus strains. Gram-negative aerobic bacteria: influenza (haemophilus) bacilli, parainfluenzae (haemophilus) bacilli, catarrhalis (moraxella), acinetobacter, Yersinia, Legionella pneumophila, Bordetella pertussis, Bordetella parapertussis, Shigella, Pasteurella, Vibrio cholerae, Parahaemolyticus, Shigella-like Pyrimonas. The activity of this product against the following Gram-negative bacteria depends on the strain, and sensitivity testing is required: Escherichia coli, Salmonella typhi, Enterobacter, Hydrophila, Klebsiella. Anaerobic bacteria: Bacteroides fragilis, Bacteroides, Clostridium perfringens, Peptostreptococcus, Fusobacterium necroticum, Propionibacterium acnes. Sexually transmitted disease microorganisms: Treponema pallidum, Neisseria gonorrhoeae, Duke (Haemophilus) bacillus. Other microorganisms: including Borrelia tenens (Lyme disease body), Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Chlamydia trachomatis, Pneumocystis carinii, Mycobacterium avium, Campylobacter, Listeria monocytogenes. The following Gram-negative bacteria are usually resistant: Proteus, Serratia, Morganella, Pseudomonas aeruginosa. The mechanism of action is the same as erythromycin, mainly binding to the 50S subunit of the bacterial ribosome, inhibiting RNA-dependent protein synthesis.
Ingredients
The main ingredient of this product is azithromycin. Its other scientific name is (2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| AzithromycinIngredients |
It inhibits bacterial protein synthesis by hindering the bacterial transpeptidation process. It has antibacterial effects on a variety of Gram-positive aerobic bacteria (such as Staphylococcus aureus, Streptococcus pyogenes, etc.), Gram-negative aerobic bacteria (such as Haemophilus influenzae, Moraxella catarrhalis, etc.), anaerobic bacteria (such as Bacteroides fragilis, Propionibacterium acnes, etc.), sexually transmitted disease microorganisms (such as Treponema pallidum, Neisseria gonorrhoeae, etc.) and other microorganisms (such as Mycoplasma pneumoniae, Chlamydia trachomatis, etc.). The mechanism of action is the same as that of erythromycin, mainly binding to the 50S subunit of the bacterial ribosome to inhibit RNA-dependent protein synthesis. More |
83905-01-5 | 39 |
Appearance
This product is white tablets or off-white granules.
Indication
1. Acute pharyngitis and acute tonsillitis caused by Streptococcus pyogenes. 2. Sinusitis, otitis media, acute bronchitis, and acute exacerbation of chronic bronchitis caused by sensitive bacteria. 3. Pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae, and Mycoplasma pneumoniae. 4. Urethritis and cervicitis caused by Chlamydia trachomatis and non-multi-drug resistant Neisseria gonorrhoeae. 5. Skin and soft tissue infections caused by sensitive bacteria.
Usage and Dosage
Azithromycin dispersible tablets are used to treat infectious diseases. Disperse with water before taking and then swallow orally. The course of treatment and usage are as follows: Adults: (1) For sexually transmitted diseases caused by Chlamydia trachomatis or sensitive Neisseria gonorrhoeae, only 1g of this product is needed for a single oral administration. (2) For the treatment of pediatric pharyngitis and tonsillitis, take 12mg/kg of body weight once a day (maximum daily dose not exceeding 0.5g) for 5 consecutive days. For the treatment of other infections: total dose of 1.5g, divided into three doses, take 0.5g of this product once a day. Or the total dose is the same, still 1.5g, take 0.5g on the first day, and then take 0.25g of this product once a day from the second to the fifth day.
Adverse Reactions
Patients tolerate this product well, and the incidence of adverse reactions is low. About 0.3% of patients discontinue treatment due to adverse reactions. Gastrointestinal reactions account for the majority of adverse reactions, and the main symptoms include diarrhea (loose stools), upper abdominal discomfort (pain or cramps), nausea, vomiting, and occasional abdominal distension. Generally, they are mild to moderate. Occasionally, reversible increases in liver aminotransferase are seen, and the incidence is similar to that of other macrolide antibiotics and penicillins. Transient mild neutropenia has been seen, but whether it is related to azithromycin has not been confirmed.
Precautions
Contraindicated in patients allergic to azithromycin, erythromycin or any other macrolide drugs
Special Population Medication
Precautions for children: Regardless of the type of infection, the recommended total dose of azithromycin in children is no more than 1500 mg. Azithromycin dry suspension is used for children weighing more than 45 kg, and the usage and dosage are the same as adults. The efficacy and safety of treating otitis media, community-acquired pneumonia in children under 6 months old, and pharyngitis or tonsillitis in children under 2 years old have not yet been determined. Precautions for pregnancy and lactation: Animal experiments have shown that this product has no effect on the fetus, but there is still a lack of experience in its use in pregnant women, so the pros and cons must be fully weighed when used in pregnant women. There is no data showing whether this product can be secreted into breast milk, so the use of lactating women must be considered with caution. Precautions for the elderly: Not yet clear.
Drug Interactions
1 It is not suitable to take it at the same time with antacids containing aluminum or magnesium, as the latter can reduce the peak blood concentration of this product; if it must be taken together, this product should be given 1 hour before or 2 hours after taking the above drugs. 2 When used in combination with theophylline, the concentration of the latter in plasma can be increased, and attention should be paid to detecting the plasma theophylline level. 3 When used in combination with warfarin, attention should be paid to checking the prothrombin time. 4 When used in combination with the following drugs, it is recommended to observe the patient closely: Digoxin increases the level of digoxin Ergotamine or dihydroergotamine Acute ergot toxicity, symptoms are severe peripheral vasospasm and dysesthesia (pain to touch) Triazolam enhances the pharmacological effect of triazolam by reducing the degradation of triazolam. Cytochrome P450 system metabolites increase the levels of carbamazepine, terfenadine, cyclosporine, cyclohexylbarbital, and phenytoin in serum. 5 When used in combination with rifabutin, the latter's toxicity will be increased.
Storage
Sealed, stored in a dry place
Packaging Specification
0.1 g (100,000 units)
Validity Period
24 months
Manufacturer
Beijing Taiyang Pharmaceutical Industry Co., Ltd.
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Founded in:
1992-06-13 -
Address:
Floor 1 to 3, Building 1, No. 10, Baocan South Street, Daxing Biomedicine Industry Base, Zhongguancun Science Park, Daxing District, Beijing -
Tax NO.:
911101056259095800 -
Registered Funds:
130 million yuan -
Website:
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Email: