Econazole Nitrate Suppository
Function and Efficacy
This product is an azole antifungal drug and a dechlorinated derivative of miconazole. It has antibacterial effects on Candida, Chromatiaceae, Coccidioides, Histoplasma, Sporothrix, etc., and also has antibacterial activity against Trichophyton, etc. This product has poor effects on Aspergillus, Sporothrix Schenckii, some dark-colored spores, Mucor, etc. The mechanism of action is to interfere with the activity of cytochrome P450, thereby inhibiting the biosynthesis of ergosterol, the main steroid of fungal cell membrane, damaging the fungal cell membrane and changing its permeability, so that important intracellular substances leak out. This product can inhibit the biosynthesis of triglycerides and phospholipids of fungi, inhibit the activity of oxidases and peroxidases, cause the accumulation of hydrogen peroxide in cells, and lead to cell submicrostructure degeneration and cell necrosis. For Candida albicans, it can inhibit the process of transformation from spores to invasive hyphae.
Ingredients
Econazole nitrate.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Econazole nitrateIngredients |
This product is an azole antifungal drug. It has antibacterial effects on Candida, Chromatiaceae, Coccidioides, Histoplasma, Sporothrix, etc. It also has antibacterial activity against Trichophyton. It has poor effects on Aspergillus, Sporothrix Schenckii, some dark-spored spores, Mucor, etc. The mechanism of action is to interfere with the activity of cytochrome P450, thereby inhibiting the biosynthesis of ergosterol, the main steroid of fungal cell membrane, damaging the fungal cell membrane and changing its permeability, resulting in leakage of important intracellular substances. It can inhibit the biosynthesis of triglycerides and phospholipids of fungi, inhibit the activity of oxidases and peroxidases, cause the accumulation of intracellular hydrogen peroxide, and lead to cell submicrostructure degeneration and cell necrosis. For Candida albicans, it can inhibit the process of transformation from spores to invasive hyphae. More |
68797-31-9 | 18 |
Appearance
This product is a milky white to slightly yellow suppository.
Indication
Used for candidal vulvovaginal disease.
Usage and Dosage
Vaginal administration: Use 1 tablet before going to bed, place deep in the vagina, 3 days as a course of treatment.
Adverse Reactions
Local irritation, itching or burning may occur occasionally.
Precautions
Not yet clear
Special Population Medication
Precautions for children: follow doctor's advice. Precautions for pregnancy and lactation: women in the first 3 months of pregnancy and lactating women are prohibited from using. Precautions for the elderly: follow doctor's advice.
Drug Interactions
Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Storage
Keep tightly closed in a cool place.
Packaging Specification
150mg
Validity Period
24 months
Manufacturer
Hubei Newland Pharmaceutical Co., Ltd.
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Founded in:
2001-04-27 -
Address:
No. 36 Dongwu Avenue, Wujiashan Taiwanese Investment Zone, Dongxihu District, Wuhan (6) -
Tax NO.:
91420112726149349L -
Registered Funds:
30 million yuan -
Website:
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Email: