Ampicillin Capsules

The antibacterial effect of this product on Gram-positive cocci and bacilli (including anaerobic bacteria) is basically the same as that of penicillin, and its effect on Enterococcus faecalis is stronger than that of penicillin. Among Gram-negative bacteria, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella, Proteus mirabilis, Salmonella, etc. are all sensitive to this product. Some Escherichia coli and some Shigella are also sensitive to this product, but most Shigella are resistant to this product. Other Enterobacteriaceae, Pseudomonas aeruginosa, Bacteroides fragilis, etc. are resistant to this product. This product has a certain antibacterial effect on Legionella and Campylobacter fetus. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls, causing the bacteria to rupture and dissolve rapidly.

The main ingredient of this product is ampicillin, and its chemical name is: 6-[D(-)-2-amino-phenylacetylamino]penicillanic acid trihydrate.

The content of this product is white or off-white powder with a slightly bitter taste.

Used for respiratory tract infections, urinary tract infections, digestive tract infections, ear, nose and throat infections, skin and soft tissue infections caused by sensitive pathogens.

Oral administration. Adults take 0.25-0.75g (1-3 tablets) at a time, 4 times a day. Children take 25mg/kg of body weight per day, 2-4 times a day.

(1) The adverse reactions of this product are similar to those of penicillin, with allergic reactions being the most common. Rash is the most common reaction, which usually occurs 5 days after medication and is in the form of urticaria or maculopapular rash; interstitial nephritis may also occur; anaphylactic shock is occasionally seen. (2) Gastrointestinal reactions such as glossitis, gastritis, nausea, vomiting, enteritis, diarrhea, and mild abdominal pain are also common. (3) Granulocytopenia and thrombocytopenia are occasionally seen in patients taking ampicillin. Antibiotic-related enteritis is rare, and a small number of patients have elevated serum alanine aminotransferase (ALT).

(1) Patients who are allergic to penicillins or cephalosporins or have a positive penicillin skin test are contraindicated. (2) Patients with uric acid kidney stones or acute gout attacks are contraindicated. (3) Patients with active peptic ulcers are contraindicated.

Precautions for children: It is forbidden to use in children under 2 years old. Precautions for pregnancy and lactation: There are no strict controlled trials for the use of ampicillin in pregnant women, so pregnant women should use this product only when it is necessary. A small amount of ampicillin can be secreted from breast milk, so breastfeeding should be suspended when breastfeeding women take the drug. Precautions for the elderly: Due to the decline of physiological renal function, the dosage should be appropriately reduced.

(1) Combined use with probenecid will prolong the half-life of this drug. (2) Ampicillin and kanamycin have synergistic antibacterial effects against Escherichia coli and Proteus. (3) Allopurinol can increase the incidence of ampicillin rash reactions, especially in hyperuricemia. (4) Ampicillin can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives.

seal

0.25g

3 years