Ribomycin Sulfate for Injection

Ribomycin sulfate is an aminoglycoside antibiotic. The antibacterial spectrum is similar to that of kanamycin, but the antibacterial effect is weaker. This product has good antibacterial activity against Escherichia coli, Klebsiella, Proteus and other Enterobacteriaceae, and also has good effects on some Staphylococci (methicillin-sensitive strains), Neisseria gonorrhoeae, and Neisseria meningitidis. It has a weak effect on Mycobacterium tuberculosis and Streptococcus, and has no effect on Pseudomonas aeruginosa and anaerobic bacteria. Bacteria have cross-resistance to this product and kanamycin. This product mainly binds to the 30S subunit of the bacterial ribosome and inhibits bacterial protein synthesis. This product is less toxic than kanamycin.

Ribomycin sulfate.

This product is suitable for various serious infections caused by sensitive Enterobacteriaceae such as Escherichia coli, Klebsiella, Proteus, Shigella, etc., such as pneumonia, sepsis, biliary tract infection, etc. It is usually used in combination with broad-spectrum semi-synthetic penicillins, cephalosporins or other antibacterial drugs.

Before use, add 2ml, 3ml, 4ml of sterile water for injection or saline to each bottle of 0.2g, 0.5g, 1g of this product respectively, and inject intramuscularly after it is completely dissolved. Adults take 1-2g per day, divided into 2 intramuscular injections; children take 20-40mg/kg per day according to body weight, divided into 2 intramuscular injections.

This product is less toxic than kanamycin, but the dosage should be slightly higher than the latter. In experimental animals, this product causes less pathological damage to the hearing and cochlea of guinea pigs than kanamycin and gentamicin. Rares, numbness, tinnitus, headache, nausea, vomiting, diarrhea, etc. are rare. Occasionally, hearing loss, dizziness, vitamin K or vitamin B deficiency, increased blood urea nitrogen and blood aminotransferase (ALT and AST) are seen. There have been 2 reports of shock.

Patients with a history of allergy to this product or aminoglycosides are contraindicated.

1. This product combined with other aminoglycosides or applied topically or systemically may increase ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. This product combined with neuromuscular blocking drugs may aggravate neuromuscular blocking effects, leading to muscle weakness, respiratory depression, etc. This product combined with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), etc., or applied topically or systemically successively, may increase ototoxicity and nephrotoxicity. 3. This product combined with cephalothin or cefazolin topically or systemically may increase nephrotoxicity. 4. This product combined with polymyxin injections, or applied topically or systemically successively, may increase nephrotoxicity and neuromuscular blocking effects. 5. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or applied sequentially to avoid aggravating nephrotoxicity or ototoxicity.

Keep tightly closed in a dry place.

1.0g

Liaoning PHARMA-UNION Pharmaceutical Co., Ltd.

• Founded in:

  2008-05-12

• Address:

  122A Xianghuai Road, Benxi Economic Development Zone

• Tax NO.:

  91210500673786474R

• Registered Funds:

  110 million yuan

• Email:

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