Cefpodoxime Proxetil Tablets

Cefpodoxime proxetil is an oral broad-spectrum third-generation cephalosporin. After entering the body, it is hydrolyzed into cefpodoxime by nonspecific esterase to exert antibacterial effects. It is effective against both Gram-positive and Gram-negative bacteria. The mechanism of action of this product is to achieve bactericidal effects by inhibiting the biosynthesis of microbial cell walls. This product is stable to beta-lactamase, so many beta-lactamase-producing microorganisms that are resistant to penicillin and cephalosporins are still sensitive to this product. This product is ineffective against some ultra-extended-spectrum beta-lactamases. In vitro and clinical infection studies have confirmed that this product is active against most of the following microorganisms: 1 Aerobic Gram-positive microorganisms: Staphylococcus aureus (including penicillinase-producing strains, but ineffective against methicillin-resistant Staphylococci), saprophytic Staphylococci, Streptococcus pneumoniae (except penicillin-resistant strains), and Streptococcus pyogenes. 2 Aerobic Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae (including beta-lactamase-producing strains), Moraxella catarrhalis, and Neisseria gonorrhoeae (including penicillinase-producing strains). This product is active against most of the following microorganisms in vitro, but its clinical significance is still unclear: 1 Aerobic Gram-positive microorganisms - Streptococcus agalactiae, Streptococcus (Groups C, F, and G). However, this product is ineffective against enterococci. 2 Aerobic Gram-negative microorganisms - Citrobacter heteromorphica, Klebsiella oxytoca, Proteus vulgaris, Providencia rettgeri, Haemophilus parainfluenzae. However, this product is inactive against most Pseudomonas and Enterobacter. 3 Anaerobic Gram-positive microorganisms - Peptostreptococcus spp.

The main ingredient of this product is cefpodoxime proxetil.

This product is a film-coated tablet. After removing the coating, it is off-white or slightly yellow.

This product is suitable for the following infections caused by sensitive bacteria: 1. Upper respiratory tract infections: for example: ear, nose and throat infections, including acute otitis media, sinusitis, tonsillitis and pharyngitis; 2. Lower respiratory tract infections: for example: community-acquired pneumonia, acute exacerbation of chronic bronchitis; 3. Simple urinary tract infections: for example: cystitis; 4. Simple skin and skin soft tissue infections: folliculitis (including purulent acne), furuncle, carbuncle, erysipelas, cellulitis, lymphangiitis (nodular) inflammation, suppurative paronychia, subcutaneous abscess, sweat glanditis, clustered acne, and combined infection of sebaceous cysts; 5. Acute simple gonococcal urethritis and cervicitis, and perianal inflammation caused by Neisseria gonorrhoeae.

Usage: Oral administration, this product should be taken after meals. Dosage: Adults: Upper respiratory tract infections including acute otitis media, sinusitis, tonsillitis and pharyngitis, etc. 100mg (1 tablet), twice a day, 5-10 days of treatment. Lower respiratory tract infection: acute exacerbation of chronic bronchitis, 200mg (2 tablets), twice a day, 10 days of treatment. Acute community-acquired pneumonia, 200mg (2 tablets), twice a day, 14 days of treatment. Simple urinary tract infection, 100mg (1 tablet), twice a day, 7 days of treatment. Acute simple gonorrhea, single dose 200mg (2 tablets). Skin and skin soft tissue infection, 400mg (4 tablets), twice a day, 14 days of treatment. Children: Acute otitis media 10mg/kg once a day, or 5mg/kg twice a day 400mg~200mg (the maximum daily dose does not exceed 400mg once a day, or 200mg twice a day), 10 days of treatment. Tonsillitis and sinusitis: 10 mg/kg/day (maximum dose not exceeding 200 mg/day, taken in two doses), course of treatment 5-10 days.

Literature reports that the following adverse reactions may occur when using this product for treatment: 1 Gastrointestinal reactions: nausea, vomiting, diarrhea, soft stools, stomach pain, abdominal pain, loss of appetite or stomach discomfort, and occasionally constipation. 2 Allergies: If rash, urticaria, erythema, itching, fever, lymph node swelling or joint pain occurs, the drug should be discontinued and treated appropriately. 3 Blood: eosinophilia, thrombocytopenia, and occasionally granulocytopenia may occur. 4 Liver: AST, ALT, ALF, LDH, etc. may increase. 5 Kidneys: BUN and Cr may increase. 6 Alternative flora: stomatitis and candidiasis may occur occasionally. 7 Vitamin deficiency: Symptoms of vitamin K deficiency (hypoprothrombinemia, bleeding tendency, etc.) and vitamin B deficiency (glossitis, stomatitis, loss of appetite, neuritis, etc.) may occur occasionally. 8 Others: dizziness, headache, and edema may occur occasionally.

1. Patients allergic to penicillin or beta-lactam antibiotics are contraindicated. 2. Patients allergic to cefpodoxime are contraindicated.

Precautions for children: The safety of the drug for use in children has not been established (little experience in use). Precautions for pregnancy and lactation: The safety of the drug for use during pregnancy has not been established, so pregnant women or women who may become pregnant should only use the drug when the benefits of treatment outweigh the risks. Precautions for the elderly: The elderly should pay attention to the following content and dosage and dosing interval, observe the patient's condition, and administer the drug with caution. (1) The elderly often have reduced physiological functions and are prone to side effects. (2) The elderly may have a tendency to bleed due to vitamin K deficiency.

Antacids or H2 receptor antagonists can reduce its absorption and lower its peak plasma concentration; probenecid can increase its plasma concentration level.

Keep away from light, tightly closed, in a cool place.

0.1 g

24 months