Cefuroxime Capsules

This product is a first-generation cephalosporin, which has good antibacterial effect on some strains of Gram-positive cocci such as non-penicillinase-producing and penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococcus, group A hemolytic Streptococcus, Streptococcus pneumoniae and viridans Streptococcus. Anaerobic Gram-positive bacteria are mostly sensitive to this product, and Bacteroides fragilis is resistant to this product. Methicillin-resistant Staphylococci and Enterococci are resistant to this product. The effect of this product on Gram-positive and Gram-negative bacteria is similar to that of cephalexin. This product has a certain effect on Neisseria gonorrhoeae, and is also active against enzyme-producing Neisseria gonorrhoeae; its activity against Haemophilus influenzae is poor.

The main ingredient of this product is cefradine, and its chemical name is (6R,7R)-7[(R)-2-amino-2-(1,4-cyclohexenyl)acetylamino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid.

The content of this product is white to off-white or light yellow powder or granules.

It is suitable for acute pharyngitis, tonsillitis, otitis media, bronchitis, pneumonia and other respiratory tract infections, urogenital tract infections and skin and soft tissue infections caused by sensitive bacteria. This product is an oral preparation and should not be used for severe infections.

For adults, take 0.25-0.5 g orally, once every 6 hours, with a maximum daily dose of 4 g. For children, take 6.25-12.5 mg/kg orally, once every 6 hours.

The adverse reactions of this product are mild and the incidence is low, about 6%. Gastrointestinal reactions such as nausea, vomiting, diarrhea, and upper abdominal discomfort are more common. The incidence of drug rash is about 1% to 3%. Pseudomembranous colitis, eosinophilia, positive reaction to direct Coombs test, peripheral blood leukocytopenia and neutrophil granulocyte reduction are seen in individual patients. A small number of patients may experience temporary increase in blood urea nitrogen, serum aminotransferase, and serum alkaline phosphatase.

This product is contraindicated in patients who are allergic to cephalosporins or have a history of anaphylactic shock or immediate reaction to penicillin.

Precautions for children: No research data is available. Precautions for pregnancy and lactation: This product can enter the fetal blood circulation through the placental barrier and can also enter the breast milk. Pregnant and lactating women should use it with caution. Precautions for the elderly: No research data is available.

1. Cephalosporins can delay the excretion of phenytoin sodium in the renal tubules. 2. Phenylbutazone combined with cephalosporin antibiotics can increase renal toxicity. 3. Combined with strong diuretics can increase renal toxicity. 4. Combined with mecillinam, it has a synergistic effect on Gram-negative rods such as Escherichia coli and Salmonella. 5. Probenecid can delay the excretion of this product.

Seal tightly and store in a cool, dark place.

0.25g

24 months.

NCPC Hebei HUAMIN Pharmaceutical Co., Ltd.

• Founded in:

  2010-04-28

• Address:

  No. 98, Hainan Road, Shijiazhuang Economic and Technological Development Zone

• Tax NO.:

  91130182554463533P

• Registered Funds:

  1.450139 million yuan

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