Imipenem and Cilastatin Sodium for Injection

Imipenem has antibacterial effects on Gram-positive and Gram-negative aerobic and anaerobic bacteria. This product is very sensitive to Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus (including enzyme-producing strains), Escherichia coli, Klebsiella, some strains of Acinetobacter, Bacteroides fragilis and other Bacteroides, Peptococcus and some strains of Peptostreptococcus. This product is also quite sensitive to Streptococcus faecalis, Streptococcus epidermidis, Haemophilus influenzae, Proteus mirabilis, Serratia marcescens, Enterobacter aerogenes, Enterobacter cloacae, Pseudomonas aeruginosa, Clostridium difficile, Clostridium difficile, etc. This product has good enzyme resistance and rarely has cross-resistance with other β-lactam drugs.

This product is a compound preparation, its components are: imipenem and cilastatin sodium.

It is suitable for the treatment of serious infections caused by sensitive Gram-positive bacteria and Gram-negative bacteria, such as sepsis, infective endocarditis, lower respiratory tract infection, abdominal infection, pelvic infection, skin and soft tissue infection, bone and joint infection, urinary tract infection and mixed infection caused by multiple bacteria.

Intravenous drip or intramuscular injection. 1 The dosage is based on imipenem, and according to the condition, 0.25-1g at a time, 2-4 times a day. For moderate infection, it can generally be given at 1g once, twice a day. Isotonic sodium chloride injection and 5%-10% glucose solution can be used as solvents for intravenous drip. For every 0.5g of drug, 100ml of solvent is used to make a 5mg/ml liquid, which is slowly dripped. 1% lidocaine injection is used as a solvent for intramuscular injection to relieve pain. 2 For patients with renal insufficiency, the dose should be adjusted according to creatinine clearance: for patients with creatinine clearance of 31-70ml/min, use 0.5g every 6-8 hours, with a maximum daily dose of 1.5-2g; for patients with creatinine clearance of 21-30ml/min, use 0.5g every 8-12 hours, with a maximum daily dose of 1.5-2g.

1. This product may cause thrombophlebitis if it is used intravenously at too fast a speed, and may cause local pain, erythema, induration, etc. when injected intramuscularly. It is advisable to change the injection site. 2. Liver: There may be an increase in aminotransferase, blood bilirubin or alkaline phosphatase. 3. Kidney: There may be an increase in blood creatinine and blood urea nitrogen. However, children often have red urine when using this drug. This is due to the discoloration caused by the drug, not hematuria. 4. There may be symptoms of the nervous system, such as muscle spasms, mental disorders, etc. 5. This product can cause gastrointestinal symptoms such as nausea, vomiting, diarrhea, and occasionally pseudomembranous colitis. 6. There may be an increase in eosinophils, a decrease in leukocytes, a decrease in neutrophils, a decrease or increase in thrombocytopenia, a decrease in hemoglobin, etc., and may cause a positive anti-human globulin (Coombs) test. 7. This product may also cause allergic reactions, such as skin itching, rash, urticaria, drug fever, etc.

It is contraindicated for those who are allergic to this product.

1 The combined use of probenecid and imipenem/cilastatin sodium can prolong the plasma half-life of imipenem and correspondingly increase its area under the plasma concentration-time curve (AUC). Studies have shown that when the two are used in combination, the half-life of imipenem can be extended by about 6%, the AUC can be increased by about 13%, and the plasma clearance rate can be decreased by about 13%. 2 When imipenem/cilastatin sodium is used in combination with aminoglycoside antibiotics, it has a synergistic antibacterial effect on certain isolated Pseudomonas. 3 The combined use of imipenem/cilastatin sodium and cyclosporine can increase neurotoxic effects. 4 The combined use of imipenem/cilastatin sodium and theophylline can cause theophylline poisoning (nausea, vomiting, palpitations, epileptic seizures, etc.). The possible mechanism is that the combined use may increase the central nervous system toxicity. 5 It has been reported that

Keep in airtight container and away from light.

0.5g: imipenem 250mg and cilastatin sodium 250mg (calculated as cilastatin)