Penicillin V Potassium Capsules

This product is a penicillin antibiotic. The antibacterial spectrum and mechanism of action are the same as penicillin. It has a killing effect on sensitive bacteria in the reproductive period by inhibiting the synthesis of bacterial cell wall mucopeptides. This product has antibacterial activity against most Gram-positive bacteria, some Gram-negative bacteria (such as Haemophilus), spirochetes and actinomycetes, but most Staphylococcus strains (more than 90%) including Staphylococcus aureus and coagulase-negative Staphylococci can produce β-lactamase to hydrolyze and inactivate this product. The activity of this product against most sensitive strains is 2-5 times weaker than that of penicillin. It has no antibacterial effect on strains that produce penicillinase.

Penicillin V potassium.

This product is a hard capsule, and the contents are off-white granules and powder.

This product is suitable for mild and moderate infections caused by penicillin-sensitive strains, including tonsillitis, pharyngitis, scarlet fever, erysipelas, etc. caused by streptococci; bronchitis, pneumonia, otitis media, sinusitis caused by pneumococci, and skin and soft tissue infections caused by sensitive staphylococci, etc. This product can also be used for spirochetal infections and as a preventive drug for recurrent rheumatic fever and infective endocarditis.

Oral. Adults: Streptococcal infection, 125-250 mg once, once every 6-8 hours, for a course of 10 days; Pneumococcal infection: 250-500 mg once, once every 6 hours, for a course of at least 2 days after the fever subsides; Staphylococcal infection, spirochete infection (Fensen angina): 250-500 mg once, once every 6-8 hours; To prevent recurrence of rheumatic fever, 250 mg once, twice a day; To prevent endocarditis, take 2 g of this product orally 1 hour before tooth extraction or upper respiratory tract surgery, and take another 1 g after 6 hours (the dose for children under 27 kg is halved). Children: According to body weight, 2.5-9.3 mg/kg once, once every 4 hours; or 3.75-14 mg/kg once, once every 6 hours; or 5-18.7 mg/kg once.

Common adverse reactions to oral penicillin V are nausea, vomiting, upper abdominal discomfort, diarrhea, and black hairy tongue. Allergic reactions include rash, urticaria and other serum sickness-like reactions, laryngeal edema, drug fever, and eosinophilia. Hemolytic anemia, leukopenia, thrombocytopenia, transient increase in serum transaminase, neurotoxicity, and nephrotoxicity are rare. Long-term or large-scale use of this product can cause superinfection with penicillin-resistant Staphylococcus aureus, Gram-negative bacilli, or Candida albicans.

It is contraindicated for patients with positive penicillin skin test reaction, those who are allergic to this product and other penicillins, and those with infectious mononucleosis.

Precautions for children: Not clear yet. Precautions for pregnancy and lactation: 1. This product can enter the fetus through the placenta, so pregnant women should use it with caution. 2. This product can be secreted into breast milk, which may cause sensitization to infants and cause diarrhea, rash, Candida infection, etc., so lactating women should use it with caution or stop breastfeeding during medication. Precautions for the elderly: Elderly patients should adjust the dosage or medication interval according to their renal function.

1. Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides can reduce the excretion of this product in the renal tubules, thereby increasing the blood concentration of this product, prolonging the blood elimination half-life (t1/2β), and the toxicity may also increase. 2. When this product is used in combination with allopurinol, the incidence of rash increases significantly, so the combination should be avoided. 3. This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram. 4. When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when either is used alone. 5. This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives. 6. Antibiotics such as chloramphenicol, erythromycin, tetracyclines, and antibacterial drugs such as sulfonamides can interfere with the bactericidal activity of this product, so it is not suitable to be used in combination with this product, especially in the treatment of meningitis or when bactericidal treatment is urgently needed.

Keep away from light, seal tightly and store in a cool dark place.

0.236g (400,000 units)

24 months

Sichuan Pharmaceutical, Inc.

• Founded in:

  2005-07-14

• Address:

  No. 18, Baiye Road, High-tech West District, Chengdu

• Tax NO.:

  91510100777457202W

• Registered Funds:

  80 million yuan

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