Prednisone Acetate Tablets

Adrenal cortical hormones have anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressive effects, and their mechanism of action is as follows: 1. Anti-inflammatory effect: This product can reduce and prevent tissue response to inflammation, thereby reducing the manifestations of inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and leukocytes at the site of inflammation, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators. 2. Immunosuppressive effect: including preventing or inhibiting cell-mediated immune responses, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, reducing the ability of immunoglobulins to bind to cell surface receptors, and inhibiting the synthesis and release of interleukins, thereby reducing the secretion of T lymphocytes to lymphoblasts.

17α,21-dihydroxypregna-1,4-diene-3,11,20-trione 464-acetate.

This product is white tablets.

It is mainly used for allergic and autoimmune inflammatory diseases. It is suitable for connective tissue diseases, systemic lupus erythematosus, severe polymyositis, severe bronchial asthma, dermatomyositis, vasculitis and other allergic diseases, acute leukemia, malignant lymphoma and other diseases suitable for other adrenal cortex hormone drugs.

1 Oral administration: generally 5-10 mg (1-2 tablets) at a time, 10-60 mg (2-12 tablets) a day. 2 For autoimmune diseases such as systemic lupus erythematosus, gastropathic syndrome, ulcerative colitis, autoimmune hemolytic anemia, etc., 40-60 mg can be given daily, and the dosage can be gradually reduced after the condition stabilizes. 3 For allergic diseases such as drug-induced dermatitis, urticaria, bronchial asthma, etc., prednisone can be given at 20-40 mg daily, and the dosage can be reduced after the symptoms are alleviated, reducing by 5 mg every 1-2 days. 4 To prevent organ transplant rejection, generally 100 mg is taken orally daily starting 1-2 days before surgery, and changed to 60 mg daily one week after surgery, and then gradually reduced.

Large doses of this product can easily cause diabetes, peptic ulcers and Cushing's syndrome-like symptoms, and have a strong inhibitory effect on the hypothalamus-pituitary-adrenal axis. Concurrent infection is the main adverse reaction.

It is not suitable for patients with hypertension, thrombosis, gastric and duodenal ulcers, mental illness, abnormal electrolyte metabolism, myocardial infarction, visceral surgery, glaucoma, etc. It is contraindicated for patients with a history of allergy to this product and adrenal cortical hormones, and for those with fungal and viral infections.

Precautions for children: Children should use with caution. Precautions for pregnancy and lactation: Pregnant and lactating women should use with caution. Precautions for the elderly: The use of glucocorticoids can easily cause high blood pressure, and elderly patients, especially postmenopausal women, are prone to osteoporosis.

1. Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. Long-term use with anticholinergics (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by them. 7. When used in combination with hypoglycemic drugs such as insulin, it can increase blood sugar in diabetic patients.

Keep away from light and store in sealed container.

5mg

36 months

Tianjin Baihai Pharmaceutical Co., Ltd.

• Founded in:

  2002-06-20

• Address:

  Fuxing Road, Shigezhuang Town, Wuqing District

• Tax NO.:

  91120222738481461F

• Registered Funds:

  9 million yuan

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