Salmon Calcitonin Nasal Spray
Function and Efficacy
It can significantly reduce the loss of bone calcium in high-turnover bone diseases, such as osteoporosis, Paget's disease, Sudeck's disease, and malignant osteolysis. It has a more significant effect on the trunk bones of postmenopausal osteoporosis than on the limbs, and is more significant for high-turnover bone diseases than low-turnover bone diseases. It can inhibit osteoclast activity and stimulate osteoblast formation and activity. Calcitonin can also increase the excretion of urinary calcium, phosphorus, and blood sodium by inhibiting osteolysis and reducing tubular reabsorption, but serum calcium will not drop below the normal range. This drug also inhibits the secretory activity of the stomach and pancreas, but does not affect gastrointestinal motility. There is evidence that this drug has an analgesic effect on patients with certain painful bone diseases. All calcitonins are similar in structure, with a single chain and 32 amino acids arranged differently. The order of amino acid arrangement depends on the species, and their effects are basically the same. The drug has a high affinity for its receptor binding sites present in certain areas of the central nervous system and its effects last longer than those of synthetic mammalian calcitonins.
Ingredients
Salmon Calcitonin
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Calcitonin salmonIngredients |
It can significantly reduce bone calcium loss in high-turnover bone diseases, such as osteoporosis, Paget's disease, Sudeck's disease and malignant osteolysis; the effect on the trunk bones of postmenopausal osteoporosis is more significant than that on the limbs, and on high-turnover bone diseases than low-turnover bone diseases; it can inhibit osteoclast activity while stimulating osteoblast formation and activity; by inhibiting osteolysis, it reduces tubular reabsorption and increases the excretion of urinary calcium, phosphorus and blood sodium, but serum calcium will not drop below the normal range; it inhibits the secretory activity of the stomach and pancreas, but does not affect gastrointestinal motility; it has an analgesic effect on patients with certain painful bone diseases. More |
47931-85-1 | 16 |
Appearance
The liquid of this product is a colorless, clear liquid in a pressure-resistant container. When the valve is pressed, the liquid will spray out in the form of mist.
Indication
1. Osteoporosis. (1) Early and late postmenopausal osteoporosis; (2) Senile osteoporosis; (3) Secondary osteoporosis, for example: corticosteroid treatment or lack of activity. In order to prevent progressive bone loss, calcium and vitamin D should be taken in appropriate amounts according to individual needs. 2. Bone pain accompanied by osteolysis and osteopenia.
Usage and Dosage
Before using the nasal spray for the first time (except for the one-spray specification), press the trigger repeatedly to start the exhaust pump until a uniform and fine aerosol is released. Once used, the spray bottle should be stored at room temperature and used up within one month. If the sprayer is blocked, it can be released by pressing the trigger forcefully. Please do not use sharp objects as this will damage the sprayer. 1. Osteoporosis 20ug daily or 40ug daily or every other day, once or in divided doses; depending on the condition and the patient's response. 2. Bone pain accompanied by osteolysis and/or osteopenia adjusts the dose according to individual needs, 40-80ug per day, 40ug can be given at one time, when a large dose is needed, it should be given in divided doses. Treat for a few days until the analgesic effect of the drug is fully exerted. In order to achieve long-term treatment,
Adverse Reactions
Nausea, vomiting, dizziness, and mild facial flushing with a feeling of warmth may occur. These side effects are dose-related and are more common with intravenous injections than with intramuscular or subcutaneous injections, which are more common with nasal sprays. There are rare reports of polyuria or rigors. These reactions usually resolve spontaneously, and only in rare cases do they require a temporary dose reduction. In rare cases, administration of salmon calcitonin has resulted in allergic reactions, and individual allergic reactions have been reported to result in tachycardia, hypotension, and collapse. Side effects are less common with nasal sprays.
Precautions
Hypersensitivity to salmon calcitonin (see ADVERSE REACTIONS).
Special Population Medication
Precautions for children: Due to the lack of sufficient information on long-term use of this product in children, the treatment time should not exceed several weeks unless the doctor believes that there is an indication for long-term treatment. Precautions for pregnancy and lactation: Although salmon calcitonin cannot pass through the placenta of animals in animal experiments, there is currently a lack of experience in the use of this product in pregnant women. Because salmon calcitonin can enter breast milk, lactating women should not use this product. Precautions for the elderly: See other items or follow the doctor's advice.
Drug Interactions
drugInteractions
Storage
Ampoules and unopened bottles of nasal spray should be stored in a refrigerator (2-8°C).
Packaging Specification
2 ml: 44 million units
Validity Period
24 months