Danazol Soft Capsules

It is a gonadotropin inhibitor that can inhibit the pituitary-ovarian axis. Due to the inhibition of pituitary gonadotropin, the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) is reduced. It can directly inhibit the production of ovarian steroid hormones, act on the estrogen receptor site of endometrial cells, and have the effect of inhibiting estrogen, causing normal and abnormal endometrium of the uterus to atrophy and become inactive, leading to anovulation and amenorrhea, which can last for up to 6 to 8 months. In the treatment of fibrous breast disease, it can make nodules disappear, relieve pain and tenderness, and may cause menstrual disorders or amenorrhea. In the treatment of hereditary angioedema, it increases the level of serum C1 lipase inhibitor, resulting in an increase in the concentration of C4 in the complement system in the serum.

Chemical name: 17-pregnane-2,4-diene-20-yn-[2,3-d]isoxazol-17-ol Molecular weight: C22H37NO2

This product is a soft capsule.

It is mainly used to treat endometriosis. It is also used to treat fibromastitis, gynecomastia, breast pain, dysmenorrhea, abdominal pain, etc. It can make the lumps disappear, soften or shrink, and make the pain disappear or alleviate. It is also used to treat precocious puberty, idiopathic thrombocytopenic purpura, hemophilia and Christmas disease, hereditary angioedema, systemic lupus erythematosus, etc.

Oral. Common dosage for adults: 1. Endometriosis, 400-800 mg per day, divided into two doses, for 3-6 months. If symptoms reappear after stopping the drug, another course of treatment can be given; (under normal liver function) 2. Fibrocystic breast disease, take the drug on the first day after the start of menstruation, 50-200 mg once, twice a day. If symptoms recur within one year after stopping the drug, the drug can be given again; 3. Hereditary angioedema, start with 200 mg once, 2-3 times a day, until the effect appears. The maintenance dose is generally 50% or less of the starting dose, and it is reduced at intervals of 1-3 months or longer, depending on the frequency of the disease before treatment.

1. More common adverse reactions: amenorrhea, breakthrough uterine bleeding, and may also cause breast reduction, hoarseness, and increased hair growth; acne, increased oiliness of the skin or hair, lower limb edema, or weight gain may occur. Symptoms are related to the dosage and are manifestations of androgen effects. 2. Less common adverse reactions: hematuria, epistaxis, gingival bleeding, cataracts (gradually blurred vision), abnormal liver function, increased intracranial pressure (manifested as severe headache, decreased vision, diplopia, vomiting), leukocytosis, acute pancreatitis, multiple neuritis, etc. 3. Rare adverse reactions include: enlarged clitoris in women and reduced testicles in men; when liver function is severely impaired, both men and women may experience yellowing of the sclera or skin. 4. The following reactions require attention if they persist (1) Due to the low efficacy of estrogen, women may have vaginal

It is contraindicated for patients with thrombosis, heart, liver, and kidney diseases, and abnormal genital bleeding.

Precautions for children: Not clear. Precautions for pregnancy and lactation: Pregnant women should not use this drug. Pregnant women who are taking the drug should terminate the pregnancy. Theoretically, this product may have androgenic effects on female fetuses. Lactating women should not take it. Precautions for the elderly: Generally, elderly patients have low physiological functions and should take it in a reduced dose (such as 100-200 mg per day).

1. When used together with insulin, it is easy to produce drug resistance; 2. When used together with warfarin, the anticoagulant effect is enhanced and bleeding is likely to occur.

seal.

10mg

24 months