Para-aminosalicylic acid isoniazid tablets

Pharmacology: This product is a chemical compound of isoniazid (INH) and para-aminosalicylic acid (PAS). INH is mainly effective against mycobacteria in the growth and reproduction period. Its mechanism of action has not yet been elucidated, and it may inhibit the synthesis of mycolic acid (myolic acid) of sensitive bacteria and cause cell wall rupture. PAS effectively delays and blocks the acetylation process of INH in the body. Therefore, this product can maintain a higher and longer INH concentration in the blood and reduce liver toxicity. After taking equal amounts of INH and this product, it was found that the INH blood concentration was only 0.03 mg/L in 12 hours, while this product still had 2.6 mg/L. The INH blood concentration was 0 in 14 hours, while this product was still as high as 2 mg/L, which was twice the MIC. This not only enhances the bactericidal effect of the drug, but also delays the development of bacterial resistance. Clinically, it has been confirmed that in combined treatment with other anti-tuberculosis drugs, the anti-tuberculosis efficacy of this product is significantly better than that of INH; and the incidence of adverse reactions such as gastrointestinal reactions, liver function damage and low white blood cells is significantly lower than that of INH. Animal tests show that the anti-tuberculosis efficacy of this crystal is about 5 times that of INH in artificially infected mice, and the therapeutic effect of this crystal at 10 mg/kg per day is significantly better than the physical mixture of INH (20 mg/kg per day) and PAS (200 mg/kg per day). Toxicology: The oral LDso of this product in mice and rabbits is 0.4g/kg and 0.8-1.6g/kg, which is twice that of INH respectively.

Aminosalicylate isoniazid.

This product is light yellow or yellow tablets or film-coated tablets.

It is used in combination with other anti-tuberculosis drugs to treat various types of pulmonary tuberculosis, endobronchial tuberculosis and extrapulmonary tuberculosis. It can also be used as a protective drug for tuberculosis-related surgeries, and can also be used to prevent tuberculosis infection and recurrence during long-term or high-dose corticosteroid and immunosuppressive therapy.

Oral prevention: 0.3g per day for adults, taken at once; 10mg/kg per day for children, not exceeding 0.3g per day, taken at once. Treatment: Adults take 5mg/kg per day orally, up to 0.3g per day, in combination with other anti-tuberculosis drugs; or 15mg/kg per day, up to 900mg, 2-3 times a week. Children take 10-20mg/kg per day, not exceeding 0.3g per day, taken at once. For some children with severe tuberculosis (such as tuberculous meningitis), the daily dose may be as high as 30mg/kg (maximum daily dose 500mg), but attention should be paid to the occurrence of liver damage and peripheral neuritis.

Occasionally, adverse reactions such as dizziness, headache, insomnia, fever, rash, nausea, fatigue, jaundice, peripheral neuritis, optic neuritis and hematocytopenia may occur.

1. It is contraindicated for patients with mental illness and epilepsy. 2. It is contraindicated for patients with severe liver dysfunction.

Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.

Not yet clear.

Keep away from light, sealed and stored in a dry place.

100mg*100s

Tentative 24 months

Chongqing Huapont Pharmaceutical Co., Ltd.

• Founded in:

  2012-06-26

• Address:

  No. 69, Renhe Xingguang Avenue, Yubei District, Chongqing

• Tax NO.:

  915000005992299001

• Registered Funds:

  450 million yuan

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