Indapamide Tablets

It is a sulfonamide diuretic that works by inhibiting the reabsorption of water and electrolytes in the dilution segment of the distal renal tubular cortex. The antihypertensive mechanism is unknown, and its diuretic effect cannot explain the antihypertensive effect, because the dose at which the antihypertensive effect occurs is much smaller than the dose of the diuretic effect. Possible mechanisms include the following aspects: regulating calcium influx into vascular smooth muscle cells; stimulating the synthesis of prostaglandins PGE2 and prostaglandins PGI2; reducing the hypersensitivity of blood vessels to vasopressor amines, thereby inhibiting vasoconstriction. This product has little or no effect on cardiac output, heart rate and rhythm when lowering blood pressure. Long-term use of this product rarely affects glomerular filtration rate or renal blood flow. This drug does not affect the metabolism of blood lipids and carbohydrates. (A group of biologically active substances derived from an unsaturated fatty acid containing a five-membered ring of twenty carbon atoms. According to the position of double bonds, the number or position of hydroxyl groups, the presence or absence of endoperoxide structures, etc., it is divided into nine categories from PGA to PGI. It has the effects of lowering blood pressure, smooth muscle contraction, regulating inflammatory response, promoting blood coagulation, immune response and counteracting other hormones.)

The main ingredient and chemical name of this product is indapamide, and its chemical name is N-(2-methyl-2,3-dihydro-1H-indolyl)-3-sulfamoyl-4-chloro-benzamide. Molecular formula: C16H16CIN3O3S Molecular weight: 365.83

This product is a sugar-coated tablet, which appears white after removing the coating.

Used to treat high blood pressure.

Common adult dosage: Oral, 2.5 mg (1 tablet), once a day.

Relatively mild and short-lived, and dose-related. 1. Less common are: diarrhea, headache, loss of appetite, insomnia, nausea, orthostatic hypotension. 2. Rare are: allergic reactions such as rash and itching; hyponatremia, hypokalemia, and hypochloremic alkalosis.

Allergic to sulfonamides, severe renal insufficiency, hepatic encephalopathy or severe hepatic insufficiency, hypokalemia.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: There is no human research on the effect on pregnancy, and no problems have been found in animal studies. It is not clear whether this product is excreted into breast milk, but no problems have occurred in human use. Precautions for the elderly: The elderly are more sensitive to antihypertensive effects and electrolyte changes, and often have changes in renal function, so caution must be exercised when using this product.

1. The diuretic and natriuretic effects of this product are weakened when it is used together with adrenal cortical hormones; 2. When this product is used together with amiodarone, it is easy to cause arrhythmia due to low blood potassium; 3. The anticoagulant effect of this product is weakened when it is used together with oral anticoagulants; 4. The natriuretic effect of this product is weakened when it is used together with non-steroidal anti-inflammatory analgesics; 5. The diuretic effect of this product is enhanced when it is used together with dopamine; 6. The antihypertensive effect of this product is enhanced when it is used together with other types of antihypertensive drugs; 7. The antihypertensive effect of this product is weakened when it is used together with sympathomimetics; 8. When this product is used in combination with lithium, the blood lithium concentration may increase and signs of overdose may appear; 9. When used in combination with large doses of salicylates, dehydrated patients may develop acute renal failure; 10. Lactic acidosis is prone to occur when used in combination with metformin.

Keep away from light and store in sealed container.

2.5 mg

24 months.