Levamisole Hydrochloride Tablets

This product is the levorotatory form of tetramisole, which can selectively inhibit succinate dehydrogenase in the muscles of the worm, so that fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscles of the worm and reducing energy production. When the worm comes into contact with it, it can depolarize the nerves and muscles, and the muscles will continue to contract and cause paralysis; the drug's cholinergic effect is conducive to the excretion of the worm. Its activity is about 1 to 2 times that of tetramisole (racemic form), but its toxic side effects are lower. In addition, the drug may have an inhibitory effect on the microtubule structure of the worm. Levamisole also has immune regulation and immune preparation functions.

The main ingredient of this product is: Levamisole hydrochloride. Its chemical name is: (S)-(-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride.

This product is a white tablet or sugar-coated tablet, which appears white after removing the coating.

It has good efficacy against ascaris, hookworm, pinworm and strongyloidiasis. Since the single dose of this product has a high efficacy, it is suitable for group treatment. It is more active than ethopropazine against adult worms and microfilariae of Bancroftian filariasis, Malayan Brugia and Onchocerca volvulus, but the long-term efficacy is poor.

① Ascaris removal: Oral, 1.5-2.5 mg/kg for adults, taken on an empty stomach or before bedtime, 2-3 mg/kg for children. ② Hookworm removal: Oral, 1.5-2.5 mg/kg, once a night, for 3 consecutive days. ③ Treatment of filariasis: 4-6 mg/kg, divided into 2-3 doses, for 3 consecutive days.

Generally mild. Nausea, vomiting, abdominal pain, etc., a few may have taste disorders, fatigue, dizziness, headache, joint pain, confusion, insomnia, fever, flu-like symptoms, low blood pressure, vasculitis, rash, photosensitivity dermatitis, etc., proteinuria, individual granulocytopenia, thrombocytopenia, a few even have agranulocytosis (usually reversible), often occurs in patients with rheumatism or tumors. In addition, it can cause immediate and Arthus allergic reactions, which may be atopic reactions caused by stimulating T cells. Individual cases may have ataxia, paresthesia or blurred vision.

It is contraindicated for patients with impaired liver and kidney function, active hepatitis, early pregnancy, or pre-existing schistosomiasis.

Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.

(1) It can be used in combination with pyrantel to treat severe hookworm infections and improve the effectiveness of expelling American hookworms. (2) It can be used in combination with thiabendazole to treat mixed intestinal nematode infections. (3) It can be used sequentially with diethylcarbamazine citrate to treat filarial infections. (4) It should not be used in combination with tetrachloroethylene to avoid increasing its toxicity.

Store in sealed container (room temperature 10-30℃).

25mg

24 months

Hainan Pharmaceutical FACTORY Co., Ltd.

• Founded in:

  2001-07-09

• Address:

  Hebei West Road, Wuzhishan City, Hainan Province

• Tax NO.:

  91469001730040768G

• Registered Funds:

  12.8 million yuan

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