Verapamil Hydrochloride Sustained Release Tablets

Verapamil hydrochloride. Chemical name: α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-isopropylphenylacetonitrile hydrochloride. Molecular weight: C27H38N2O4·HCl

This product is off-white tablets.

1. The starting dose is 180 mg, taken orally once in the morning. For patients with an increased response to verapamil (i.e., the elderly or those with a thin body), 120 mg taken orally once a day may be safe as a starting dose. The dose may be increased based on weekly assessments of efficacy and safety, and 24 hours after the last dose. 2. If a satisfactory therapeutic effect is not achieved with 180 mg of Verapamil extended-release tablets taken orally once a day, the dose may be increased in the following ways: (1) 240 mg taken orally in the morning; (2) 180 mg taken orally once in the morning and evening; or 240 mg taken orally once in the morning and 120 mg taken orally once in the evening; (3) 240 mg taken orally every 12 hours. 3. When switching from regular tablets to Verapamil extended-release tablets, the total dose may remain unchanged.

1. Take the recommended single dose and total daily dose as the starting dose and gradually adjust the dose upward. Serious adverse reactions are rare. 2. Adverse reactions with an incidence of 1-10%: constipation (7.3%); dizziness, mild headache (3.5%); nausea (2.7%); hypotension (2.5%); headache (2.2%). Peripheral edema (2.1%); congestive heart failure (1.8%); sinus bradycardia (1.4%), I, II or III degree atrioventricular block (1.2%); rash (1.2%); fatigue; palpitations; increased transaminase, with or without increased alkaline phosphatase and bilirubin. This increase is sometimes transient and may even disappear with continued use of verapamil. 3. Adverse reactions with an incidence of 1%: hypotension; heart

1. Severe left ventricular dysfunction. 2. Hypotension (systolic blood pressure less than 90 mmHg) or cardiogenic shock. 3. Sick sinus syndrome (except for patients with functional pacemakers). 4. II or III degree atrioventricular block (except for patients with functional pacemakers). 5. Patients with atrial flutter or atrial fibrillation and atrioventricular bypass. 6. Patients known to be allergic to verapamil hydrochloride.

Precautions for children: Safety and efficacy in children under 18 years of age have not been established. Precautions for pregnancy and lactation: Verapamil can cross the placenta. The pros and cons of using it in pregnant women should be weighed. Verapamil can be secreted into breast milk, and breastfeeding should be interrupted during the use of verapamil. Precautions for the elderly: The elimination half-life may be prolonged in elderly patients, and it must be considered that liver or kidney dysfunction is more common in the elderly. Generally, a lower starting dose should be used in the elderly.

Cytotoxic drugs such as cyclophosphamide, vincristine, procarbazine, prednisone, vinblastine, doxorubicin, and cisplatin reduce the absorption of verapamil.

seal.

10s

24 months

North China Pharmaceutical Company.Ltd

• Founded in:

  1992-12-20

• Address:

  No. 388, Heping East Road, Shijiazhuang City

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  91130100104397700P

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