Azasetron Hydrochloride and Sodium Chloride Injection

Azasetron hydrochloride is a selective 5-HT3 receptor antagonist, which has a significant inhibitory effect on nausea and vomiting caused by anticancer drugs such as cisplatin. Animal studies have shown that the affinity of azasetron hydrochloride for the 5-HT3 receptor in the rat cerebral cortex is about 410 times stronger than that of metoclopramide, twice that of ondansetron, and basically the same as that of granisetron.

Azasetron hydrochloride. Chemical name: (plusmn;) N-(1-azabicyclo[2,2,2]oct-3-yl)-6-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride.

Used for gastrointestinal symptoms such as nausea and vomiting caused by cytotoxic chemotherapy.

10 mg once a day (1 vial at a time), diluted with 40 ml of normal saline, slowly injected intravenously 30 minutes before chemotherapy.

Some patients experience thirst, constipation, headache, dizziness, abdominal discomfort, etc. The above reactions are mild and do not require special treatment. In severe cases, there have been reports of anaphylactic shock. Therefore, the patient's reaction should be closely observed during use. If abnormalities occur, the drug should be discontinued immediately and appropriate treatment should be given.

1. Patients who are allergic to this type of drug (5-HT3 receptor blocker) and this product are contraindicated; 2. Patients with gastrointestinal obstruction are contraindicated; 3. Newborns, pregnant women and breastfeeding women should use with caution.

Precautions for children: Use with caution in newborns. Precautions for pregnancy and lactation: Use with caution in pregnant women and lactating women.

1. This product will become turbid or crystallize when used with alkaline injection (such as furanine, methotrexate, fluorouracil, piretanide, etc.) or etoposide injection, so it is necessary to dilute this product with sodium chloride injection before using it with the above alkaline drugs. 2. This product may reduce the content of this product when used with etoposide injection or fluoxetine sodium injection, so it should be used within 6 hours after preparation. 3. This product will become turbid or produce precipitation when used with diazepam injection, so it should be avoided to use it with them.

Keep in a light-proof and airtight container. The validity period is tentatively 12 months.

50ml: Azasetron hydrochloride 10mg and sodium chloride 0.45g

Yangtze River Pharmaceutical Group Sichuan Hairong Pharmaceutical Co., Ltd.

• Founded in:

  2001-08-17

• Address:

  No. 802, South Section of Rainbow Avenue, Dujiangyan City, Chengdu City, Sichuan Province

• Tax NO.:

  91510181730231740X

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  50 million yuan

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