Loxoprofen Sodium Tablets

Pharmacological action: Loxoprofen sodium is a prodrug, which is converted into active metabolites in the body after being absorbed by the digestive tract. Its active metabolites exert analgesic, anti-inflammatory and antipyretic effects by inhibiting the synthesis of prostaglandins. Toxicological study: Reproductive toxicity: When rats were given loxoprofen sodium at a dose of 8 mg/kg, the number of corpora lutea and implantation decreased, the stillbirth rate increased, the fetal mortality rate increased, the body weight decreased and the development was slightly delayed. Loxoprofen sodium can delay delivery in rats and can be secreted through their milk.

Loxoprofen sodium.

This product is a yellow film-coated tablet, which appears white or off-white after removing the coating.

Rheumatoid arthritis, osteoarthritis, low back pain, frozen shoulder, cervical shoulder-wrist syndrome, as well as analgesia and anti-inflammation after surgery, trauma and tooth extraction, and antipyretic and analgesic for acute upper respiratory tract inflammation.

Oral administration after meals. Chronic inflammatory pain: Adults take 60 mg (1 tablet) each time, three times a day; Acute inflammatory pain: Take 60-120 mg (1-2 tablets) at a time. The dosage can be increased or decreased according to age and symptoms, and the maximum daily dosage should not exceed 180 mg (3 tablets).

Loxoprofen sodium is a prodrug. It has no irritation to the gastrointestinal tract before being absorbed into the blood, and has no obvious therapeutic effect. It only works after being absorbed into the blood and converted into active metabolites. Therefore, it has no obvious irritation to the gastrointestinal tract, has good tolerance, and has low side effects. Digestive system discomfort is more common, such as abdominal pain, stomach discomfort, nausea, vomiting, loss of appetite, constipation, heartburn, etc., sometimes there will be rash, itching, edema, drowsiness, headache, palpitations, etc., occasionally shock, acute renal insufficiency, nephrotic syndrome, interstitial pneumonia, anemia, leukopenia, thrombocytopenia, eosinophilia, and elevated AST, ALT, ALP, etc.

The following patients are contraindicated to use this product. 1. Patients with peptic ulcer; 2. Patients with severe liver and kidney damage; 3. Patients with severe heart failure; 4. Patients with severe hematological abnormalities; 5. Patients who are allergic to this product; 6. Patients with asthma caused by taking non-steroidal anti-inflammatory analgesics in the past; 7. Women in late pregnancy and lactation.

Precautions for children: The safety of medication for children is not yet clear. Precautions for pregnancy and lactation: 1. The safety of medication during pregnancy has not yet been determined. Therefore, when treating pregnant or potentially pregnant women, medication should only be given when the benefits of treatment outweigh the risks. 2. Animal experiments have reported delayed delivery and migration into breast milk, leading to contraction of the fetal arterial tube. Therefore, do not give medication in late pregnancy and during lactation. Precautions for the elderly: This product is safer for the elderly, but it should still be started at a small dose, and the patient's condition should be closely observed and medication should be given with caution.

1. When this product is used simultaneously with coumarin anticoagulants and sulfonylurea hypoglycemic drugs, the effects of these drugs will be increased, and these drugs should be used in reduced doses. 2. When used in combination with new quinolone antibiotics (enoxacin, etc.), it may sometimes cause cramps. 3. When used in combination with sulfonylurea hypoglycemic drugs, it can enhance the hypoglycemic effect of these drugs, so it is necessary to reduce the dose. 4. When used in combination with thiazide diuretics, it can weaken the diuretic hypotensive effect of these drugs. 5. When used in combination with lithium preparations, it may increase the lithium concentration in the blood and cause lithium poisoning, so the dose should be reduced when used in combination.

Keep away from light and store in sealed container.

60mg

Tentatively 24 months.

Eisai Liaoning Pharmaciutical Co., Ltd.

• Founded in:

  2011-12-19

• Address:

  No. 39, Pingtai 2nd Street, Benxi Economic and Technological Development Zone

• Tax NO.:

  912105005873118435

• Registered Funds:

  50 million yuan

• Email:

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