Calcium folinate tablets

This product is a formyl derivative of tetrahydrofolate. It is mainly used to rescue high-dose methotrexate and other folic acid antagonists. The main function of methotrexate is to bind to dihydrofolate reductase, blocking the conversion of dihydrofolate to tetrahydrofolate, thereby inhibiting DNA synthesis. After entering the human body, this product is converted into tetrahydrofolate by tetrahydrofolate reductase, which can effectively counteract the toxic reaction caused by methotrexate. This product can limit the degree of damage to normal cells caused by methotrexate and reverse the reaction of methotrexate to bone marrow and gastrointestinal mucosa, but it has no obvious effect on the existing methotrexate neurotoxicity.

Keep away from light and store in sealed container.

This product is slightly yellow or light yellow tablets.

1. Mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.). 2. Used to prevent severe toxic effects caused by overdose or high-dose treatment of methotrexate. 3. Megaloblastic anemia caused by folic acid deficiency. 4. When used in combination with fluorouracil, it is used to treat advanced colon cancer and rectal cancer.

1 As a "rescue" therapy for methotrexate, the commonly used dose is 5-15 mg, taken orally once every 6-8 hours for 2 consecutive days. The blood concentration of methotrexate is controlled below 5×10-8 mol/L according to the results of blood concentration determination. 2 As a detoxification of pyrimethamine or trimethoprim, the daily oral dose is 5-15 mg, depending on the poisoning situation. 3 For megaloblastic anemia, take 15 mg orally daily. 4 When used in combination with fluorouracil, take 20-30 mg/m2 of body surface area orally, half an hour after taking fluorouracil.

Rarely, allergic reactions such as rash, hives, or asthma may occur occasionally.

It is contraindicated in pernicious anemia or megaloblastic anemia caused by vitamin B12 deficiency.

The use of this product in large doses together with barbiturates, primidone or phenytoin sodium may affect the anti-epileptic effect.

Keep away from light, seal tightly, and store in a cool place.

15 mg (calculated as C20H23N7O7)