Diphylline Injection
Function and Efficacy
The antiasthmatic effect of this product is similar to that of theophylline. The cardiac stimulant effect is only 1/20~1/10 of that of aminophylline. It has less effect on the heart and nervous system. It is especially suitable for asthma patients with tachycardia. This product has a direct relaxant effect on the smooth muscle of the respiratory tract. Its mechanism of action is relatively complex. In the past, it was believed that it was caused by inhibiting phosphodiesterase and increasing the intracellular cAMP content. Recent experiments have shown that the bronchodilator effect of theophylline is partly due to the release of endogenous adrenaline and noradrenaline. In addition, theophylline is a purine receptor blocker that can counteract the contractile effect of adenine and other substances on the respiratory tract. Theophylline can enhance the contraction force of the diaphragm, especially when the diaphragm contraction is weak, so it helps to improve respiratory function.
Ingredients
Diprophylline Tablets
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| DiprophyllineIngredients |
The antiasthmatic effect of this product is similar to that of theophylline, and its cardiac stimulant effect is only 1/20~1/10 of that of aminophylline, and its effect on the heart and nervous system is less. It is especially suitable for asthma patients with tachycardia. This product has a direct relaxant effect on the smooth muscle of the respiratory tract. Its mechanism of action includes inhibiting phosphodiesterase to increase the intracellular cAMP content, releasing endogenous adrenaline and norepinephrine to cause bronchial dilation, acting as a purine receptor blocker to counteract the contractile effect of adenine on the respiratory tract, and enhancing the contractility of the diaphragm to improve respiratory function. More |
479-18-5 | 11 |
Appearance
This product is a colorless clear liquid.
Indication
It is used the same as aminophylline, especially for asthma patients with tachycardia.
Usage and Dosage
Intravenous drip: For severe asthma attacks, 1-2 g daily added to 2000-4000 ml of 5% glucose solution and dripped intravenously.
Adverse Reactions
1 Occasionally, there are adverse reactions such as dry mouth, nausea, palpitations, and polyuria. 2 Large doses can cause central nervous system excitement, which can be prevented by taking sedatives.
Precautions
Patients who are allergic to this product, active peptic ulcers and uncontrolled convulsive diseases are contraindicated
Special Population Medication
Precautions for children: The plasma clearance rate of newborns may be reduced and the serum concentration may increase, so it should be used with caution. Precautions for pregnancy and lactation: This product can pass through the placental barrier and can also be secreted into breast milk and excreted with breast milk. It should be used with caution by pregnant women, parturients and lactating women. Precautions for the elderly: The plasma clearance rate of the elderly is reduced and the potential toxicity is increased. It should be used with caution in patients over 55 years old.
Drug Interactions
It should not be used with aminophylline.
Storage
Keep away from light and store in a sealed container.
Packaging Specification
2ml:0.25g
Validity Period
24 months
Manufacturer
Changzhou Lanling Pharmaceutical Co., Ltd.
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Founded in:
1979-01-01 -
Address:
No. 352, Laodong East Road, Changzhou -
Tax NO.:
91320400137158984C -
Registered Funds:
25 million yuan -
Website:
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Email: