Norvancomycin Hydrochloride for Injection

This product has good antibacterial effect on most Gram-positive bacteria such as Staphylococcus aureus and methicillin-sensitive and -resistant strains of coagulase-negative Staphylococci, various streptococci, Streptococcus pneumoniae and Enterococcus.

The main component of this product is (S?)-(3S,6R,7R,22R,23S,26S,36R,38?R)-44[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-?-L-lyso-hexopyranosyl)-beta;-D-glucopyranosyl]oxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,3

This product is light brown powder or freeze-dried block.

This product is suitable for intravenous infusion for endocarditis, osteomyelitis, pneumonia, sepsis or soft tissue infection caused by Staphylococcus (including methicillin-resistant strains that are sensitive to this product). Penicillins or cephalosporins cannot be used for patients who are allergic to penicillin, or patients with severe staphylococcal infection who are ineffective after the above antibiotics, can choose vancomycin. This product is also used to treat enterococcal endocarditis and Corynebacterium (diphtheroid) endocarditis in patients who are allergic to penicillin. It is used to treat arteriovenous shunt infections caused by Staphylococcus in hemodialysis patients who are allergic to penicillin or not allergic to penicillin.

Before use, add an appropriate amount of injection water to dissolve. Slow intravenous drip: Adults 0.8g-1.6g (800,000-1.6 million units) per day, divided into 2-3 intravenous drips. Children 16mg-24mg/kg (16,000-24,000 units/kg) per day, divided into 2 intravenous drips

A small number of patients may experience rash, nausea, phlebitis, etc. This product may also cause tinnitus, hearing loss, and renal damage. Some patients may also experience transient peripheral blood leukocytopenia and elevated serum aminotransferase; rapid injection may cause allergic reactions such as decreased blood pressure and even cardiac arrest, as well as wheezing, dyspnea, rash, redness of the upper body (red neck syndrome), chest and back muscle spasms, etc.

Allergic to vancomycin antibiotics

Precautions for children: Newborns and infants must also use this drug with caution. Blood drug concentrations should be monitored if conditions permit and the dosage should be adjusted accordingly. Precautions for pregnancy and lactation: 1. Intravenous administration can cross the placenta and cause damage to the eighth cranial nerve of the fetus. Therefore, pregnant women should use this drug with caution after fully weighing the pros and cons in life-threatening situations or when other drugs are ineffective or cannot be used for serious diseases. 2. After intravenous administration, it is widely distributed in most body fluids and can be excreted in breast milk. When lactating women must use this drug for treatment, they should fully weigh the pros and cons to decide whether to use the drug. Precautions for the elderly: This product is highly likely to cause ototoxicity and nephrotoxicity (hearing loss) when used in elderly patients. Since the renal function of elderly patients declines with age, the dosage must be adjusted when used.

1. The combination or sequential application of aminoglycosides, amphotericin B injection, aspirin, other salicylates, bacitracin (injection), bumetanide injection, capreomycin, carmustine, cisplatin, cyclosporine, ethacrynic acid injection, furosemide injection, streptozotocin, paromomycin and polymyxins with norvancomycin may increase the potential for ototoxicity and/or nephrotoxicity; hearing loss may occur, and may continue to progress to deafness even after drug discontinuation. The reaction may be reversible, but often becomes permanent. Hearing must be monitored when this product is used in combination or sequentially with other deafness-causing antibacterial drugs. Since norvancomycin is often used in combination with aminoglycosides for the treatment of bacterial endocarditis and streptococcal and coryneform endocarditis, it can also be used to treat drug-resistant staphylococcal infections, or if the above patients are allergic to penicillin, renal function tests and blood drug concentration monitoring are required to adjust the dosage or dosing interval or change the drug. 2. When antihistamines, buclizine, cyclizine, phenothiazines, thioxanthenes, trimethobenzylamine, etc. are used in combination with this product, they may mask ototoxic symptoms such as tinnitus, dizziness, and vertigo. 3. It is incompatible with alkaline solutions and may precipitate when it encounters heavy metals.

Keep tightly closed in a cool, dark place.

0.4 g (calculated as C65H73Cl2N9024)

24 months

North China Pharmaceutical Company.Ltd

• Founded in:

  1992-12-20

• Address:

  No. 388, Heping East Road, Shijiazhuang City

• Tax NO.:

  91130100104397700P

• Registered Funds:

  1,715,730,370 yuan

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