Levothyroxine Sodium Tablets

1. Levothyroxine sodium will increase the anticoagulant effect. 2. Levothyroxine sodium will increase the level of phenytoin sodium in the blood. 3. Anticonvulsants such as carbamazepine and phenytoin sodium accelerate the metabolism of levothyroxine sodium and displace thyroxine from plasma proteins. 4. When this product is used together with cardiac glycosides, the dosage of cardiac glycosides must be adjusted accordingly. 5. Levothyroxine sodium will also increase the effect of sympathomimetic drugs. 6. Levothyroxine sodium increases the sensitivity of catecholamine receptors, thereby increasing the response of tricyclic antidepressants. 7. Cholestyramine reduces the absorption of levothyroxine sodium. When taking oral contraceptives at the same time, the dosage of levothyroxine sodium needs to be increased.

Levothyroxine sodium. Its chemical name is: O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine monosodium salt.

This product is white tablets.

It is suitable for long-term replacement therapy of congenital hypothyroidism (cretinism) and hypothyroidism caused by various reasons in children and adults. It can also be used for simple goiter, chronic lymphocytic thyroiditis, and suppression (and replacement) therapy after thyroid cancer surgery. Sometimes it can be used for hyperthyroidism

For adults, the initial daily dose is 25-100 μg, which can be increased by 25-50 μg every 2-4 weeks until normal metabolism is maintained. The general maintenance dose is 50-200 μg/day. For elderly patients or patients with cardiovascular disease, the initial dose is 12.5-25 μg, which can be increased every 3-4 weeks, with each increase of 12.5-25 μg. After administration, the patient should be closely observed for increased heart rate, arrhythmia, and changes in blood pressure. If necessary, the dose should be temporarily increased or reduced.

Symptoms of overdose include angina pectoris, arrhythmia, palpitations, diarrhea, vomiting, tremor, excitement, headache, restlessness, insomnia, sweating, hot flashes, weight loss, skeletal muscle cramps, etc. These symptoms usually disappear after reducing the dosage or stopping the drug for a few days.

It is contraindicated for patients with non-hypothyroid heart failure and tachyarrhythmia, and for patients who are allergic to the drug.

Precautions for children: For neonates and children with hypothyroidism or cretinism, refer to the following table for dosage: Recommended dosage (daily) or follow doctor's advice: Age Daily dosage (mg) By weight (mg/kg) 0-6 months 25-50 micrograms (8-10 micrograms/kg body weight) 7-12 months 50-70 micrograms (6-8 micrograms/kg body weight) 2-5 years old 75-100 micrograms (5-6 micrograms/kg body weight) 6-12 years old 100-150 micrograms (4-5 micrograms/kg body weight) 12 years old and above 15 Precautions for pregnancy and lactation: During thyroid replacement therapy, close monitoring is required to avoid low or high thyroid function, so as to avoid adverse effects on the fetus and infant. Trace amounts of thyroid hormone can be excreted from breast milk. Precautions for the elderly: The dosage of levothyroxine sodium tablets must be used with great caution for elderly patients. It should start with a small dose, and the interval between dose increases should be longer, that is, the dose should be increased slowly, and the blood thyroxine level should be monitored regularly.

1. Levothyroxine sodium will increase the anticoagulant effect. 2. Levothyroxine sodium will increase the level of phenytoin sodium in the blood; 3. Anticonvulsants such as carbamazepine and phenytoin sodium accelerate the metabolism of levothyroxine sodium and displace thyroxine from plasma proteins. 4. When this product is used together with cardiac glycosides, the dosage of cardiac glycosides must be adjusted accordingly. 5. Levothyroxine sodium will also increase the effect of sympathomimetic drugs. 6. Levothyroxine sodium increases the sensitivity of catecholamine receptors, thereby enhancing the effect of tricyclic antidepressants. 7. Cholestyramine reduces the absorption of levothyroxine sodium. When taking oral contraceptives at the same time, the dosage of this product needs to be increased.

Keep away from light and store in a sealed container below 25℃.

50 micrograms

24 months