Tazobactam

This product is a compound preparation of piperacillin and tazobactam sodium. Piperacillin is a broad-spectrum semi-synthetic penicillin antibiotic, and tazobactam is a new type of irreversible competitive beta-lactamase inhibitor. This product has antibacterial effects on piperacillin-sensitive bacteria and the following bacteria that are resistant to piperacillin due to the production of beta-lactamase.

Piperacillin Sodium/Tazobactam Sodium

This product is suitable for moderate to severe infections caused by β-lactamase-producing bacteria that are resistant to piperacillin but sensitive to piperacillin/tazobactam.

Dilute an appropriate amount of this product with 20 ml, and after it is fully dissolved, immediately add it to 250 ml of liquid and drip it intravenously for at least 30 minutes each time. The course of treatment is 7-10 days. The course of treatment for hospital-acquired pneumonia is 7-14 days, and it can be adjusted according to the condition and bacteriological examination results. The common dose for adults and adolescents with normal renal function is 4.5g of federal tazoxan every 8 hours. The total daily dose of medication increases or decreases according to the severity and location of the infection. The dose range can be 2.25g to 4.5g of federal tazoxan every 6 hours, 8 hours or 12 hours. For hemodialysis patients, the maximum dose is 2.25g each time, once every 8 hours, and 0.75g of federal tazoxan is added after each hemodialysis.

Skin reactions: such as rash, itching, etc. Gastrointestinal reactions: such as diarrhea, nausea, vomiting, etc. Local reactions: irritation reaction at the injection site, pain, phlebitis, thrombophlebitis and edema, etc. Other reactions: thrombocytopenia, fever, fever with eosinophilia, elevated transaminase, etc. These reactions occur when this product is combined with aminoglycosides. This product occasionally sees the following adverse clinical phenomena: maculopapular rash, herpes, urticaria, eczema, irritability, dizziness, anxiety, etc.; other reactions: rhinitis, dyspnea, etc.

This product is contraindicated in patients who are allergic to penicillins, cephalosporins or beta-lactamase inhibitors.

Aminoglycosides: In in vitro tests, this product is the same as aminoglycosides and can inactivate aminoglycosides. When this product is used with tobramycin, the area under the curve, renal clearance and urinary excretion of tobramycin will decrease by 11%, 32% and 38% respectively, because piperacillin/tazobactam may inactivate tobramycin. In patients with severe renal insufficiency, such as hemodialysis patients, the pharmacokinetics of tobramycin will change when it is combined with piperacillin. Probenecid: When used in combination with this product, the half-life of piperacillin and tazobactam can be extended. Vancomycin: When this product is used in combination with vancomycin, the pharmacokinetics are not affected. When subcutaneously injecting heparin, oral anticoagulants or other drugs that may affect blood coagulation and platelet function, coagulation function monitoring should be considered. This product cannot be mixed with other drugs in syringes or bottles. When this product is used with other antibiotics, it must be administered separately. This product must not be mixed with solutions containing sodium bicarbonate, and must not be added to blood products or hydrolyzed protein solutions.

Keep in a dark and airtight container in a dry and cool place. The validity period is tentatively set at two years.

Zhuhai Free Trade Zone Lizhu Synthetic Pharmaceutical Co., Ltd.

• Founded in:

  1993-09-09

• Address:

  No. 22 Lianfeng Road, Zhuhai Free Trade Zone

• Tax NO.:

  91440400617499024L

• Registered Funds:

  128.28 million yuan

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