Irbesartan Capsules

This product is an angiotensin II (AngI) receptor inhibitor, which can inhibit the conversion of AngI to AngI, and can specifically antagonize angiotensin converting enzyme 1 receptor (AT1). Its antagonism to ATI is greater than AT28500 times. It selectively blocks the binding of AngII to AT1 receptor, inhibits vasoconstriction and the release of aldosterone, and produces a hypotensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, other hormone receptors, nor does it inhibit ion channels related to blood pressure regulation and sodium balance.

Chemical name: 2-butyl-3-[4-[2-(1H-tetrazol-5-yl)phenyl]benzyl]-1,3-diazaspiro[4,4]non-1-en-4-one.

The content of this product is white or off-white powder or granules.

Hypertension

Oral. The recommended starting dose is 1 tablet (0.15g) once a day. Depending on the condition, it can be increased to 2 tablets (0.3g) once a day. For severe hypertension and when the blood pressure is still not reduced satisfactorily after the increase in medication, a small dose of diuretics (such as thiazides) or other antihypertensive drugs can be added.

Common adverse reactions are: headache, dizziness, palpitations, etc., and occasional cough, which are generally mild and transient, and most patients can tolerate it by continuing to take the medicine. Urticaria and angioneurotic edema rarely occur. Literature reports that the incidence of adverse reactions of this product is greater than 1%: indigestion, heartburn, diarrhea, skeletal muscle pain, fatigue and upper respiratory tract infection, but there is no significant difference compared with the blank control group. The incidence is greater than 1%, but lower than the control group: abdominal pain, anxiety, nervousness, chest pain, pharyngitis, nausea and vomiting, rash, tachycardia, etc. The incidence of hypotension and orthostatic hypotension is about 0.4%.

Do not use if you are allergic to this product.

Precautions for children: There is no data on the safety of the drug for patients under 18 years old. Precautions for pregnancy and lactation: Precautions for pregnant and lactating women. Precautions for the elderly: Elderly patients do not need to adjust the dose when using this product.

There is no significant interaction between this product and hydrochlorothiazide, digoxin, warfarin, and nifedipine. However, when used in combination with diuretics, attention should be paid to insufficient blood volume or hypotension caused by low sodium. When used in combination with potassium-sparing diuretics (such as triamterene, etc.), elevated blood potassium should be avoided. The combination with digitalis drugs such as digoxin, β-blockers such as atenolol, and calcium antagonists such as nifedipine does not affect the pharmacokinetics of each other.

Store in sealed container (10~30°C).

0.15 g

36 months

Zhuhai Rundu Pharmaceutical Co., Ltd.

• Founded in:

  1999-12-30

• Address:

  No. 6, Airport North Road, Sanzao Town, Jinwan District, Zhuhai City

• Tax NO.:

  91440400192520640G

• Registered Funds:

  334.893286 million yuan

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