Anthraquinone ointment

The main pharmacological effects of this product include anti-epithelial cell proliferation, induction of epithelial cell differentiation and anti-inflammatory effects. Specifically, it blocks the pathological signal substances expressed by abnormal immune system in psoriasis by inhibiting the activity of protein kinase C in keratinocytes and polymorphonuclear leukocytes, inhibiting the secretion of interleukin-1, 6, 8 and tumor necrosis factor α by human peripheral blood monocytes; and by reducing the amount of transforming growth factor-α in keratinocytes and its affinity with epidermal growth factor receptors, thereby producing anti-keratinocyte proliferation and anti-inflammatory effects. It can cause proliferation of mouse tail granular cells and down-regulate the expression of transglutaminase (TGase) mRNA, indicating that it has the effect of inducing epithelial cell differentiation. It produces anti-inflammatory effects by inhibiting the production of reactive oxygen species by polymorphonuclear leukocytes induced by phorbol esters.

The main ingredients of this product and their chemical names: 1,8-dihydroxy-9-anthraquinone

This product is a yellow ointment.

This product is mainly used for plaque psoriasis vulgaris.

Usage 1. Concentration-increasing therapy: When starting treatment, use a low concentration for at least 5 days. After the skin has adapted, increase the concentration from 0.05%, 0.1%, 0.25%, 0.5%, 0.8%, 1.0% to 3%. Outpatients can be treated once a day, apply the medicine before going to bed, wash it off with soap the next morning, and apply moisturizer during the day to keep the skin lubricated. Inpatients can be treated twice a day, morning and evening. A tar bath before each treatment can increase the efficacy. 2. Short-term contact therapy: After testing different concentrations and contact times, it was found that a 3% concentration as the final dose, washed off after 20 minutes of action, and treated once a day is the optimal concentration and contact time; low-concentration, short-term contact therapy can also be used, that is, 0.

The main adverse reactions are irritation to the skin, causing redness, burning, itching, etc. The nails can be dyed reddish brown and clothes can be stained yellow.

1; When used in combination with corticosteroids, it can reduce the irritation of anthralin and shorten the clearance period of skin lesions. However, due to the high recurrence rate of corticosteroids and the rebound of pustular psoriasis, the combined use of anthralin and corticosteroids is still worth considering. 2; When used in combination with urea, urea can increase drug transdermal penetration and reduce the concentration of anthralin, thereby reducing inflammatory irritation to the skin. 3; Salicylic acid can prevent anthralin from being oxidized to anthrone and has the effect of protecting anthralin. 4; Alkaline amines can inactivate anthralin by promoting its oxidation. After short-term contact treatment, applying fat-soluble amines can inhibit the inflammatory response caused by anthralin retained in the stratum corneum.

Precautions for children: This experiment has not been conducted and there are no reliable references. Precautions for pregnancy and lactation: It is not known whether anthralin will cause harm to the fetus or may affect fertility when used in pregnant women, so it is not recommended for pregnant women. There is no data to support the effects of anthralin on fetal growth, development and functional improvement. Precautions for the elderly: It is not clear yet.

The main adverse reactions are irritation to the skin, causing redness, burning, itching, etc. The nails can be dyed reddish brown and clothes can be stained yellow.

Protect from light, seal tightly and store in a cool place.

0.1%

24 months

Hainan HEALTH CARE Laboratories Limited

• Founded in:

  1996-11-25

• Address:

  Guilinyang Industrial Zone, Meilan District, Haikou City, Hainan Province

• Tax NO.:

  91460100620025532X

• Registered Funds:

  $5.32 million

• Email:

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