Compound Glycyrrhizin Tablets

． Anti-inflammatory effect (1) Anti-allergic effect Glycyrrhizic acid glycoside has anti-allergic effects such as inhibiting local allergic necrosis reaction (Arthus Phenomenon) and inhibiting Schwartzman phenomenon (Shwartzman Phenomenon) in rabbits. It can enhance the inhibitory effect of corticosteroids on stress response and antagonize the anti-granulation and thymic atrophy effects of hormones. It has no effect on the exudation of hormones. (2) Inhibitory effect on arachidonic acid metabolic enzymes Glycyrrhizic acid glycoside can directly bind to phospholipase A2, the initiator enzyme of arachidonic acid metabolic pathway, and to lipoxygenase, which acts on arachidonic acid to produce inflammatory mediators, selectively inhibiting the phosphorylation of these enzymes and inhibiting their activation. 2. Immunomodulatory effect Glycyrrhizic acid glycoside has the following immunomodulatory effects in in vitro experiments: 1) Regulation of T cell activation; 2) Induction of gamma interferon; 3) Activation of NK cells; 4) Promotion of extrathymic T lymphocyte differentiation. 3. Inhibition of experimental hepatocyte damage In the rat hepatocyte cell line cultured in invitro, glycyrrhizic acid glycoside has the effect of inhibiting hepatocyte damage caused by carbon tetrachloride. 4. Inhibition of viral proliferation and inactivation of viruses In the mouse MHV (mouse hepatitis virus) infection experiment, the administration of glycyrrhizic acid glycoside can prolong the number of days of survival; in the rabbit vaccinia virus (Vacciniavirus) pox prevention experiment, it has the effect of preventing pox; in the in vitro experimental system, the inhibition of the proliferation of herpes viruses and the inactivation of viruses have also been observed. It has been reported that glycine and methionine can inhibit the reduction of urine volume and sodium excretion caused by oral administration of glycyrrhizic acid glycoside to rats.

Glycyrrhizin

This product is a white sugar-coated tablet.

Treat chronic liver disease and improve abnormal liver function. Can be used to treat eczema, dermatitis and urticaria.

Adults usually take 2-3 tablets at a time, and children take 1 tablet at a time, 3 times a day after meals. The dosage can be increased or decreased according to age and symptoms.

The actual frequency of side effects during the use of this preparation has not yet been investigated. Important side effects: Pseudoaldosteronism (frequency unknown): Symptoms of pseudoaldosteronism such as hypokalemia, increased blood pressure, sodium and fluid retention, edema, decreased urine volume, and weight gain may occur. Therefore, during medication, full attention should be paid to observation (serum potassium value, etc.). If abnormal conditions are found, medication should be stopped. In addition, symptoms of rhabdomyolysis such as weakness, low muscle strength, muscle pain, limb cramps, and paralysis may also occur. If CK (CPK) is found to be elevated and myoglobin in blood and urine is elevated, the drug should be stopped and appropriate treatment should be given.

The following patients should not be given this medicine: 1. Patients with aldosteronism, myopathy, hypokalemia (may aggravate hypokalemia and hypertension). 2. Patients with advanced liver cirrhosis who tend to have elevated blood ammonium (the metabolites of methionine contained in this preparation can inhibit urea synthesis, thus reducing the ability to handle ammonia).

Precautions for children: Children take 1 tablet at a time, 3 times a day, orally after meals. Precautions for pregnancy and lactation: Pregnant and lactating women should be given the drug with caution after weighing the benefits of treatment outweigh the risks. Precautions for the elderly: Based on clinical application experience, the elderly are prone to adverse reactions of hypokalemia, so they need to be given with caution under close observation.

Drugs that require attention when used in combination: loop diuretics, uric acid, furosemide, and other thiocyanate-type diuretics, and antihypertensive diuretics, potassium trichloride, thiazide, chlorthalidone, etc.; Clinical symptoms and treatment methods: Hypokalemia (fatigue, low muscle strength) may occur, and full attention should be paid to observing the serum potassium value. Mechanism and consequences: Diuretics can enhance the potassium excretion effect of glycyrrhizic acid contained in the preparation, thereby further lowering serum potassium.

Store at room temperature.

21s

24 months