Ketoprofen sustained-release tablets (Ⅱ)

This product is an aromatic propionic acid derivative and a non-steroidal anti-inflammatory analgesic. In addition to inhibiting cyclooxygenase, this product also has a certain effect of inhibiting lipoxygenase and reducing bradykinin, thereby reducing the pain sensation at the site of inflammatory injury. Because bradykinin and prostaglandins can cause pain together. Bradykinin can also cause uterine contraction, so this product is used for dysmenorrhea, mainly by inhibiting bradykinin, thereby inhibiting uterine contraction and analgesia to achieve therapeutic effects. This product also has a certain central analgesic effect. Acute toxicity test results: rat oral LD50 is 101mg/kg.

The main ingredients of this product and their chemical names are: The main ingredient of this product is ketoprofen, and its chemical name is α-methyl-3-benzoyl-phenylacetic acid

This product is white or off-white tablets.

It is mainly used for rheumatic or rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, dysmenorrhea, etc. It can also be used for joint sprains, soft tissue injuries, fracture pain and postoperative pain.

The dosage of this product should be individualized. For adults, take it orally during meals. The usual dosage is 200 mg per day, once a day. The maximum daily dose should not exceed 200 mg.

1. Gastrointestinal reactions are common, such as stomach pain or discomfort, flatulence, nausea, vomiting, loss of appetite, diarrhea, constipation, etc. In severe cases, upper gastrointestinal ulcers, bleeding and perforation may occur. 2. Allergic reactions: allergic dermatitis, skin itching, exfoliative dermatitis, laryngeal edema, bronchospasm (allergic), etc. 3. Eyes: blurred vision, retinal hemorrhage. 4. Cardiovascular system: arrhythmia, increased blood pressure, palpitations. 5. Central nervous system: dizziness, headache, tinnitus, hearing loss, mental tension, depression, hallucinations, drowsiness, numbness of the limbs 6. Liver and kidney: liver damage, decreased renal function, interstitial nephritis

1. Those who are allergic to aspirin or other non-steroidal anti-inflammatory drugs; 2. Those with active peptic ulcer.

Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Use with caution in the elderly.

1. When used with alcohol or other non-steroidal anti-inflammatory drugs, gastrointestinal adverse reactions and bleeding tendencies may increase. Long-term use with acetaminophen may increase toxic side effects on the kidneys. 2. When used with anticoagulants such as heparin and dicoumarol and platelet aggregation inhibitors, there is an increased risk of bleeding. 3. When used with furosemide, the latter's sodium excretion and antihypertensive effects are weakened. 4. When used with verapamil and nifedipine, the blood concentration of this product increases. 5. This product can increase the blood concentration of digoxin. When used together, be sure to adjust the dose of digoxin. 6. This product can enhance the effect of oral antidiabetic drugs. 7

Keep away from light and store in sealed container.

0.2g

18 months

Sichuan QILI Pharmaceutical Co., Ltd.

• Founded in:

  2001-09-24

• Address:

  No. 6 Tianhong Road, High-tech Zone, Chengdu

• Tax NO.:

  91510000MA61Y0AT5F

• Registered Funds:

  60 million yuan

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