Penicillin Potassium

1 Chloramphenicol, erythromycin, tetracyclines, and sulfonamides can interfere with the activity of this product, so it is not suitable to drip in the same bottle. 2 Probenecid, aspirin, indomethacin, phenylbutazone and sulfonamides reduce the renal tubular secretion of penicillin and prolong the serum half-life of this product. Penicillin can enhance the anticoagulant effect of warfarin. 3 This product is incompatible with heavy metals, especially copper, zinc, and mercury. 4 Adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C group, etc. to penicillin intravenous infusion will cause turbidity. 5 This product and aminoglycoside antibiotics drip in the same bottle may lead to a decrease in the antibacterial activity of both, so it cannot be placed in the same container for administration.

It is suitable for various infections caused by sensitive bacteria, such as abscesses, bacteremia, pneumonia and endocarditis.

1. Allergic reaction: Allergic reaction to penicillin is common, including urticaria and other types of rashes, leukopenia, interstitial nephritis, asthma attacks, and serum sickness reactions; anaphylactic shock is rare. Once it occurs, it must be rescued on the spot, and the airway must be kept open, oxygen inhalation, and treatment measures such as epinephrine and glucocorticoids must be used. 2. Toxic reaction: It is rare, but when a large dose of this product is intravenously infused or intrathecally administered, convulsions, muscle spasms, coma, and severe mental symptoms (penicillin encephalopathy) may occur due to excessive concentration of drugs in the cerebrospinal fluid. This reaction is more common in infants, the elderly, and patients with renal insufficiency. 3. Herxheimer's reaction and treatment contradiction: When penicillin is used to treat diseases such as syphilis and leptospirosis, symptoms may be aggravated due to the death of pathogens, which is called Herxheimer's reaction; treatment contradictions are also seen in syphilis patients, which is caused by the rapid disappearance of syphilis lesions after treatment, while tissue repair is relatively slow or the fibrous tissue in the lesion site contracts, hindering organ function. 4. Double infection: Double infection such as penicillin-resistant Staphylococcus aureus, Gram-negative bacilli or Candida albicans may occur; the use of large doses of potassium penicillin in patients with renal insufficiency may lead to hyperkalemia.

It is contraindicated in patients with a history of allergy to penicillins or a positive penicillin skin test.

Penicillin has good antibacterial effect on hemolytic streptococci and other streptococci, Streptococcus pneumoniae and non-penicillinase-producing staphylococci. It has moderate antibacterial effect on enterococci. Neisseria gonorrhoeae, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces bovis, Streptobacillus candida, Listeria monocytogenes, Leptospira and Treponema pallidum are sensitive to this product. This product also has certain antibacterial activity against Haemophilus influenzae and Bordetella pertussis, and other Gram-negative aerobic or facultative anaerobic bacteria are less sensitive to this product. This product has good antibacterial effect on Clostridium, Peptostreptococcus anaerobic bacteria and melanin-producing Bacteroides, but has poor antibacterial effect on Bacteroides fragilis. Penicillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

Keep tightly closed in a cool, dark and dry place.

North China Pharmaceutical Company.Ltd

• Founded in:

  1992-12-20

• Address:

  No. 388, Heping East Road, Shijiazhuang City

• Tax NO.:

  91130100104397700P

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  1,715,730,370 yuan

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