Didanosine dispersible tablets
Function and Efficacy
It is a nucleotide analog that can competitively participate in the synthesis of new nucleotide chains during DNA or RNA replication or reverse transcription, and terminate the continued synthesis of the chain, making it impossible for HIV RNA to be reverse transcribed or integrated into the host cell chromosome through proviral DNA, thereby inhibiting HIV reverse transcriptase activity and blocking infection.
Ingredients
Didanosine
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| DideoxyinosineIngredients |
It is a nucleotide analog that can competitively participate in the synthesis of new nucleotide chains during DNA or RNA replication or reverse transcription, and terminate the continued synthesis of the chain, making it impossible for HIV RNA to be reverse transcribed or integrated into the host cell chromosome through proviral DNA, thereby inhibiting HIV reverse transcriptase activity and blocking infection. More |
69655-05-6 | 13 |
Appearance
This product is off-white to light orange tablets with spots on the surface.
Indication
Used in combination with other antiviral drugs to treat type 1 HIV infection.
Usage and Dosage
For patients with body weight greater than 60kg, 200mgbid or 400mgqd. For patients with body weight less than 60kg, 125mgbid or 250mgqd. Children: 120mg/m2bid. Dosage interval is 12 hours. For patients with renal impairment, reduce the dose or extend the medication interval.
Adverse Reactions
The main toxicities are pancreatitis and peripheral neuropathy. Diarrhea, nerve damage, chills/fever, erythema/pruritus, abdominal pain, fatigue, headache, pain, nausea, vomiting, depression, hyperlipidemia.
Precautions
Didanosine dispersible tablets are contraindicated in patients with significant allergies to didanosine or other ingredients in the formula.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Lactating mothers should stop breastfeeding when taking the drug. Precautions for the elderly: Not yet clear.
Drug Interactions
Be careful when taking with tetracycline, antacids containing magnesium or aluminum. If the absorption of the drug is affected by gastric acidity (such as ketoconazole, dapsone), it should be taken at least 2 hours before this product.
Storage
Store in a sealed bottle at 15-30°C.
Packaging Specification
100mg
Validity Period
24 months
Manufacturer
Hangzhou Minsheng Pharmaceutical Co., Ltd.
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Founded in:
1963-11-29 -
Address:
No. 36, Linping Avenue, Donghu Street, Linping District, Hangzhou City, Zhejiang Province -
Tax NO.:
913301101430685558 -
Registered Funds:
88.97 million yuan -
Website:
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Email: