Propylthiouracil Enteric-coated Tablets

Pharmacological action: This product is a thiourea antithyroid drug that mainly inhibits the synthesis of thyroxine. Its mechanism of action is to inhibit thyroid endoperoxidase, prevent the oxidation of iodide taken into the thyroid gland and the coupling of tyrosine, thereby hindering the synthesis of thyroid hormone T4 and triiodothyronine T3. Since this product cannot directly counteract thyroid hormones, it can only produce therapeutic effects after the thyroid hormones that have been produced are exhausted, so the effect is slow. In addition, this product also inhibits the deiodination of T4 in peripheral tissues to produce T3.

Propylthiouracil

This product is an enteric-coated tablet, which appears white after removing the coating.

It is used for various types of hyperthyroidism, including toxic diffuse goiter (Graves' disease). In Graves' disease, it is especially suitable for: 1. Patients with mild disease and mild to moderate thyroid enlargement; 2. Children, adolescents and elderly patients; 3. Patients with recurrence after thyroid surgery but not suitable for radioactive 131I treatment; 4. Preparation before surgery; 5. As an adjuvant treatment for 131I radiotherapy

Oral medication. 1 Adult dosage (1) The treatment of hyperthyroidism is divided into three stages. Treatment stage: 300-400 mg (6-8 tablets) per day, taken in 3-4 times. For severe hyperthyroidism, the dosage can be increased appropriately. The maximum dosage is 600 mg (12 tablets) per day. After the symptoms are controlled, the dosage is gradually reduced, which usually takes 1-3 months; reduction stage: the dosage can be reduced as appropriate according to the condition, blood pressure and blood TSH level. The dosage can be reduced by 50-100 mg (1-2 tablets) at a time, and the dosage can be reduced every 3-4 weeks; maintenance stage: 50-150 mg (1-3 tablets) per day, and the medication needs to be taken for 6-12 months or even longer. (2) Preoperative preparation for hyperthyroidism: Taking this drug before surgery

1. The most common adverse reactions are rash or skin itching, and some rashes may develop into exfoliative dermatitis. 2. The adverse reactions of the blood system are more serious, with mild granulocytopenia being the most common; severe granulocytopenia, thrombocytopenia, prothrombin reduction or factor VII reduction being rare; aplastic anemia may also be seen. 3. Other adverse reactions include loss of taste, nausea, vomiting, upper abdominal discomfort, joint pain, dizziness, headache, vasculitis, and lupus erythematosus-like syndrome. 4. Rare adverse reactions include hepatitis (jaundice may occur, and jaundice may last for up to 10 weeks after discontinuation of the drug), interstitial pneumonia (with cough and shortness of breath), nephritis and vasculitis involving the kidneys.

The following patients are contraindicated to use this product: 1. Those who are allergic to thiourea drugs; 2. Those with nodular goiter and hyperthyroidism; 3. Patients with thyroid cancer; 4. Breastfeeding women; 5. Severe liver damage; 6. Severe leukocytosis.

Precautions for children: Hypothyroidism should be avoided during medication for children. Precautions for pregnancy and lactation: Use with caution for pregnant women and prohibit use for lactating women. Precautions for the elderly: Elderly patients, especially those with renal impairment, should use a reduced dosage. If hypothyroidism is found, thyroid tablets should be added.

1. When used in combination with anticoagulants, it can enhance the anticoagulant effect; 2. Sulfonamides, para-aminosalicylic acid, phenylbutazone, barbiturates, phentolamine, tolazoline, vitamin B12, sulfonylureas, etc. have the effect of inhibiting thyroid function and causing thyroid enlargement, so caution should be exercised when using this drug in combination; 3. When taking this drug, avoid taking it in combination with iodine-containing drugs or foods to prevent the condition from worsening, increasing the need for antithyroid drugs or prolonging the duration of medication.

Keep in a light-proof, sealed and dry place. The validity period is tentatively 18 months.

50mg

18 months