Compound Glycyrrhizin Capsules

Pharmacological effects: 1. Anti-inflammatory effects (1) Anti-allergic effects: Glycyrrhizic acid glycoside has anti-allergic effects such as inhibiting local allergic reactions (Arthus Phenomenon) in rabbits and inhibiting Schwartzman phenomenon (Shwartzman Phenomenon). For corticosteroids, it enhances the hormone's inhibitory effect on stress response and antagonizes the hormone's anti-granulation and thymic atrophy effects. It has no effect on the exudation of hormones. (2) Inhibitory effect on arachidonic acid metabolic enzymes Glycyrrhizic acid glycoside can directly bind to phospholipase A2, the initiator enzyme of the arachidonic acid metabolic pathway, and to lipoxygenase, which acts on arachidonic acid to produce inflammatory mediators, selectively inhibiting the phosphorylation of these enzymes and inhibiting their activation. 2. Immunomodulatory effect: Glycyrrhizic acid glycoside has the following immunomodulatory effects in in vitro tests: (1) Regulation of T cell activation; (2) Induction of gamma interferon; (3) Activation of NK cells; (4) Promotion of extrathymic T lymphocyte differentiation. 3. Inhibition of experimental hepatocyte damage In the rat hepatocyte cell line cultured in invitro, glycyrrhizic acid glycoside has the effect of inhibiting hepatocyte damage caused by carbon tetrachloride. 4. Inhibition of viral proliferation and inactivation of viruses In the mouse MHV (mouse hepatitis virus) infection experiment, glycyrrhizic acid glycoside can prolong the survival of mice; in the rabbit vaccinia virus (Vacciniavirus) pox prevention experiment, it has the effect of preventing pox; in the in vitro experimental system, the inhibition of the proliferation of herpes virus and the inactivation of viruses were also observed. It has been reported that glycine and methionine can inhibit the decrease in urine volume and sodium excretion caused by oral administration of glycyrrhizic acid glycoside to rats.

The compound preparation of compound glycyrrhizic acid capsules has the following components: each capsule contains 25 mg of glycyrrhizic acid, 25 mg of glycine, and 25 mg of methionine. As excipients, it also contains appropriate amounts of lactose, calcium carbonate, microcrystalline cellulose, sodium carboxymethyl starch, talc, magnesium stearate and povidone K30.

This product is a capsule, and the contents are white to slightly yellow powder or granules.

Treat chronic liver disease and improve abnormal liver function. Can be used to treat eczema, dermatitis and alopecia areata.

Adults usually take 2-3 capsules at a time, and children take 1 capsule at a time, 3 times a day, orally after meals. The dosage can be increased or decreased according to age and symptoms.

The actual frequency of adverse reactions during the use of this preparation has not yet been investigated. Important adverse reactions: Pseudoaldosteronism (frequency unknown), which may cause hypokalemia, increased blood pressure, sodium and fluid retention, edema, decreased urine volume, weight gain and other pseudoaldosteronism symptoms. Therefore, during medication, it is necessary to observe (serum potassium value, etc.), and if abnormal conditions are found, the drug should be stopped. In addition, symptoms of rhabdomyolysis such as weakness, low muscle strength, muscle pain, limb cramps, and paralysis may also occur. If CK (CPK) is found to be elevated, and myoglobin in blood and urine is elevated, the drug should be stopped and appropriate treatment should be given.

(The following patients should not be given this medicine) 1. Patients with aldosteronism, myopathy, hypokalemia (it may aggravate hypokalemia and hypertension). 2. Patients with advanced liver cirrhosis who tend to have elevated blood ammonia (the metabolites of methionine contained in this preparation can inhibit urea synthesis, thus reducing the ability to handle ammonia).

Precautions for children: Children take 1 tablet at a time, 3 times a day, orally after meals. Precautions for pregnancy and lactation: Pregnant and lactating women should use the drug with caution after weighing the benefits of treatment outweigh the risks. Precautions for the elderly: Based on clinical application experience, the elderly are prone to adverse reactions of hypokalemia, so they need to be administered with caution under close observation.

1. Precautions when using combined medications: When used in combination with loop diuretics, uric acid, furosemide, thiazide and antihypertensive diuretics, trichloromethiazide, chlorthalidone, etc., hypokalemia (fatigue, low muscle strength) may occur, and full attention should be paid to observing serum potassium values. 2. Mechanism and consequences: Diuretics can enhance the potassium excretion effect of glycyrrhizic acid contained in the preparation, further lowering serum potassium.

Sealed and stored in greenhouse.

Each capsule contains 25mg of glycyrrhizic acid, 25mg of glycine, and 25mg of DL-methionine

36 months

Weifang Zhongshi Pharmaceutical Co., Ltd.

• Founded in:

  1993-02-11

• Address:

  No. 123, Beihainan Road, Fangzi District, Weifang City, Shandong Province

• Tax NO.:

  91370700613572116C

• Registered Funds:

  48.36252537 yuan

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