Ketoprofen extended-release tablets
Function and Efficacy
It can be quickly and completely absorbed in the gastrointestinal tract. When healthy subjects took a single dose of 150 mg, the blood concentration reached the peak value 2 to 3 hours after administration, the half-life (t1/2) was 2.61 hours, the peak time (tmax) was 2.03 hours, the peak concentration (Cmax) was 5.401mu;g/ml, and the area under the curve (AUC) was 33.136mu;g/(mlh). This product exists in the plasma mainly in the form of the original drug, hydroxylated metabolites and corresponding glucuronic acid metabolites. The binding rate of this product to albumin in plasma is 99%, and about 60% of the drug is mainly excreted from the urine in the form of glucuronic acid conjugates.
Ingredients
The main chemical component is ketoprofen: alpha;-methyl-3-benzoylphenylacetic acid.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| KetoprofenIngredients |
It can be quickly and completely absorbed in the gastrointestinal tract. When healthy subjects took a single dose of 150 mg, the blood concentration reached the peak value 2 to 3 hours after administration, the half-life (t1/2) was 2.61 hours, the peak time (tmax) was 2.03 hours, the peak concentration (Cmax) was 5.401μg/ml, and the area under the curve (AUC) was 33.136μg/(ml·h). This product exists in the plasma mainly in the form of the original drug, hydroxylated metabolites and the corresponding glucuronic acid metabolites. The binding rate of this product to albumin in plasma is 99%, and about 60% of the drug is mainly excreted from the urine in the form of glucuronic acid conjugates. More |
22071-15-4 | 44 |
Appearance
White tablets.
Indication
Rheumatic or rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, dysmenorrhea, etc.
Usage and Dosage
Oral administration: Adults: 75 mg once, twice a day.
Adverse Reactions
1. Gastrointestinal reactions are more common, such as stomach pain, discomfort, nausea, diarrhea, etc.; 2. Allergic dermatitis, tinnitus, dizziness, drowsiness, blurred vision, etc. are occasionally seen; 3. Rarely, high blood pressure, arrhythmia, abnormal liver and kidney function, gastrointestinal ulcers, bleeding, hearing loss, etc. are seen.
Precautions
1. It is contraindicated for patients with active gastrointestinal ulcer or bleeding. 2. It is contraindicated for patients who are allergic to this product, aspirin or other non-steroidal anti-inflammatory analgesics.
Special Population Medication
Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Use with caution in the elderly.
Drug Interactions
Not yet clear.
Storage
Keep away from light and store in a sealed container.
Packaging Specification
75mg
Validity Period
Tentative 24 months
Manufacturer
Fuan Pharmaceutical Group Ningbo Team Pharmaceutical Co., Ltd.
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Founded in:
1992-08-12 -
Address:
No. 366, Anping Road, Zhaobaoshan Street, Zhenhai District, Ningbo City, Zhejiang Province -
Tax NO.:
91330211144072003N -
Registered Funds:
415 million yuan -
Website:
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Email: