Bisoprolol Fumarate Capsules

This product is a selective β1 adrenergic receptor blocker, clinically used to lower blood pressure. Within the therapeutic dose range, this product has no obvious membrane stabilizing effect or intrinsic sympathomimetic effect. At high doses (20 mg), it can inhibit β2 adrenergic receptors (β2 receptors are mainly located in bronchial and vascular smooth muscles). The selectivity for β1 receptors is 4 times that of atenolol.

The main ingredients and chemical name of this product: 1-[4-[[2-(1-methylethoxy)-ethoxy]-methyl]-phenoxy]-3-[(1-methylethyl)amino]-2-propanol fumarate.

This product is a capsule, and the contents are white granules or powder.

For the treatment of hypertension, it can be used alone or in combination with other antihypertensive drugs.

The use of this product must be based on the principle of individualization. Usually the initial dose is 5 mg once a day, orally. Some patients may be suitable for an initial dose of 2.5 mg (such as bronchospasm). If the antihypertensive effect of 5 mg is not enough, the dose can be increased to 10 mg-20 mg. When the patient has liver damage (hepatitis or cirrhosis) or renal insufficiency (inosine clearance rate is less than 40 ml/min), the initial dose is 2.5 mg per day, and caution should be exercised when increasing the dose.

1. Allergy to this product. 2. Cardiogenic shock. 3. Hypotension. 4. Obvious heart failure. 5. Sick sinus syndrome and clear sinus bradycardia. 6. Second or third degree atrioventricular block. 7. Bronchial asthma.

1. Allergy to this product 2. Cardiogenic shock 3. Hypotension 4. Obvious heart failure 5. Sick sinus syndrome and clear sinus bradycardia 6. Second or third degree atrioventricular block 7. Bronchial asthma

Precautions for children: There is no information on the use of this product in children. Precautions for pregnancy and lactation: It is not clear whether this product is secreted in human milk. Pregnant and lactating women should not use it. Precautions for the elderly: No dosage adjustment is required for elderly patients. However, the dosage must be adjusted in cases of obvious renal or liver dysfunction.

This product should not be used in combination with other beta blockers. When this product is used in combination with reserpine and guanethidine, the beta receptor blocking effect of this product can be increased, resulting in excessive reduction of sympathetic activity, and close monitoring should be performed. Patients receiving clonidine treatment should stop taking this product a few days before clonidine is stopped if the medication is to be discontinued. This product should be used with caution when used in combination with drugs that have myocardial depression or atrioventricular conduction blockade, such as verapamil, diltiazem, and disopyramide, because additive effects may occur. Reserpine increases the metabolism of this product and shortens its elimination half-life, but the initial dose does not need to be adjusted. This product has no effect on the prothrombin time of patients taking warfarin.

Sealed, store in a cool, dry place.

2.5 mg

24 months

Simcere Pharmaceutical Co., Ltd.

• Founded in:

  1998-09-10

• Address:

  No. 99, Huakang Road, Jiangbei New District, Nanjing, Jiangsu Province

• Tax NO.:

  91320100135665907G

• Registered Funds:

  1.60281382 million yuan

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