Propylthiouracil Tablets

Antithyroid drugs. Its mechanism of action is to inhibit peroxidase in the thyroid gland, thereby preventing the iodination of tyrosine and the condensation of iodinated tyrosine in the thyroid gland, thereby inhibiting the synthesis of thyroxine. At the same time, it inhibits the conversion of T4 to T3 in peripheral tissues, causing the content of more active T3 in serum to decrease rapidly.

The main component of this product is propylthiouracil. Its chemical name is 6-propyl-2-thio-2,3-dihydro-4 (1H) pyrimidinone. Molecular formula: C7H10N2OS Molecular weight: 170.24

This product is white tablets.

It is used for various types of hyperthyroidism, especially for: ① patients with mild disease and mild to moderate thyroid enlargement; ② adolescents, children and elderly patients; ③ patients with recurrence after thyroid surgery who are not suitable for radioactive 131I treatment; ④ preoperative preparation; ⑤ as an adjuvant treatment for 131I radiotherapy.

For the treatment of hyperthyroidism in adults, the starting dose is generally 300 mg per day, ranging from 150 to 400 mg depending on the severity of the disease, taken orally in divided doses, with a maximum daily dose of 600 mg. The dose is gradually reduced after the disease is controlled, and the maintenance dose is 50 to 150 mg per day, adjusted according to the disease; the starting dose for children is 4 mg/kg per day, taken orally in divided doses, and the maintenance dose is reduced as appropriate.

Common adverse reactions include headache, dizziness, joint pain, swollen salivary glands and lymph nodes, and gastrointestinal reactions; there are also allergic reactions such as rash and drug fever, and some rashes can develop into exfoliative dermatitis. Some patients may suffer from jaundice and toxic hepatitis. The most serious adverse reaction is agranulocytosis, so blood tests should be conducted regularly during medication. When the white blood cell count is lower than 4x109/L or the neutrophil count is lower than 1.5x109/L, the medication should be discontinued or adjusted as directed by the doctor.

It is contraindicated for patients with severe liver damage, severe leukocyte deficiency, and allergy to thiourea drugs.

This product combined with oral anticoagulants can increase the efficacy of the latter. Sulfonamides, para-aminosalicylic acid, phenylbutazone, barbiturates, phentolamine, tolazoline, vitamin B12, sulfonylureas, etc. can inhibit thyroid function and cause goiter, so be careful when using this product. In addition, the intake of high-iodine foods or drugs can aggravate hyperthyroidism, increase the amount of antithyroid drugs required or prolong the duration of medication, so you should avoid taking iodine before taking this product.

Keep in a light-proof and airtight container.

50mg

Taishan City Xinning Pharmaceutical Co., Ltd.

• Founded in:

  2005-06-24

• Address:

  No. 223, Renxiao Road, Taicheng Town, Taishan City

• Tax NO.:

  91440781776913130X

• Registered Funds:

  100 million yuan

• Email:

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