Isosorbide dinitrate cream

The main pharmacological effect of isosorbide dinitrate (ISDN) is to relax vascular smooth muscle. ISDN is metabolized in the body to form isosorbide mononitrate (ISMN), which releases nitric oxide (NO). NO is the same as endothelial relaxing factor, activating guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) in smooth muscle cells, thereby relaxing vascular smooth muscle, dilating peripheral arteries and veins, and having a stronger dilating effect on veins. Venous dilation causes blood to remain in the periphery, reducing the amount of blood returning to the heart, and reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arterial dilation reduces peripheral vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Coronary artery dilation increases coronary perfusion. The overall effect is to reduce myocardial oxygen consumption, increase oxygen supply, and relieve angina pectoris.

Isosorbide dinitrate, 15% cream formulated in an anhydrous oil base.

This product is a white or milky white cream with an emulsion base.

1. Treat and prevent angina pectoris. 2. Can also be used to treat heart failure when digitalis or diuretics are not effective enough.

It is advisable to start with a small dose and gradually increase the dose. Squeeze the cream to the required length according to the scale, and evenly apply it on the paper with scales printed on it. Each scale is equivalent to 0.2g of isosorbide dinitrate. Apply the entire area of the paper, that is, an area of 5cm x 5cm, and apply it to the left chest area (fixed with adhesive tape). Apply once a day (once every 8 hours if necessary) before going to bed.

1. Headache, which is easy to occur when first used. 2. Hypotension, accompanied by dizziness, nausea, vomiting, sweating and even collapse. 3. Facial flushing and body heat. 4. Occasionally, skin rash or even exfoliative dermatitis occurs.

1. Cerebral hemorrhage or head trauma, because this product can increase intracranial pressure. 2. Patients with severe anemia may increase the burden on the heart when using this product. 3. Patients with glaucoma are prohibited from using this product, because this product can increase intraocular pressure. 4. Patients with myocardial infarction have hypotension and tachycardia. 5. Patients with hypertrophic obstructive cardiomyopathy may increase the left ventricular outflow tract pressure difference when using nitrates. 6. Severe renal impairment. 7. Severe liver impairment may increase the risk of denatured hemoglobin. 8. In the gastrointestinal tract of infants and young children, nitrates are rapidly converted into nitrites, which can be rapidly absorbed and are very toxic to hemoglobin.

Precautions for children: In the gastrointestinal tract of infants and young children, nitrates are rapidly converted to nitrites, which are rapidly absorbed and very toxic to hemoglobin. Precautions for pregnancy and lactation: Pregnant women can use this drug if needed. It is not clear whether it is secreted in breast milk. Precautions for the elderly: There is no abnormality in the use of this drug by the elderly.

1 Isosorbide dinitrate can enhance the effects of other vasodilators. When used in combination with other antihypertensive drugs, the orthostatic hypotensive effect of isosorbide dinitrate can be more prominent. 2 Indomethacin can inhibit the vasodilatory effect of isosorbide dinitrate.

Keep tightly closed in a cool place.

10g: 1.5g

24 months