Parthenolide
20554-84-1
Pharmaceutical Grade
98%
SHANGHAI
0.1kg/as needed
2018-09-30
Ectoine sodium salt monohydrate Ectoine sodium sa
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Product Description
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Seller Information
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Description
application
The sesquiterpene lactone compound parthenolide is a compound extracted from parthenium, which was originally used to treat skin infections, rheumatism and migraine. Recent studies have shown that parthenolide can inhibit the growth of prostate cancer, breast cancer, gastric cancer, leukemia cancer, kidney cancer, lung cancer, colon adenocarcinoma, medulloblastoma, and other cancer cells. It can treat skin cancer caused by ultraviolet rays. Studies on its mechanism of action have found that parthenolide can inhibit the activation of the transcription factor NF-κB, and its activity may be mainly due to the Michael addition reaction between the mercapto group on Cys38 of the p65/NF-κB subunit and the laughter lactone. Since NF-κB is an important gene that regulates tumor invasion, metastasis, and drug resistance, inhibiting the activation of NF-κB may increase the sensitivity of tumors to apoptosis caused by tumor suppressors. Recently, Jordan, Dr. CT and colleagues of the University of Rochester School of Medicine in New York have discovered that parthenolide can eliminate stem cells that cause acute and chronic myeloid leukemia without damage to normal stem cells, which may be fundamentally To suppress leukemia recurrence, the unique mechanism of action of parthenolide has attracted widespread attention.Basic Info-
Product Name:
(-)-Parthenolide
Other Name:Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one,2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-,(1aR,4E,7aS,10aS,10bR)-;Germacra-1(10),11(13)-dien-12-oic acid,4,5α-epoxy-6β-hydroxy-,γ-lactone;Parthenolide;(1aR,4E,7aS,10aS,10bR)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one;(-)-Parthenolide;119325-19-8;120852-67-7;344906-67-8
CAS No.:20554-84-1
Molecular Formula:C15H20O3
InChIKeys:InChIKey=KTEXNACQROZXEV-PVLRGYAZSA-N
Molecular Weight:248.318
Exact Mass:248.32
DSSTox ID:DTXSID2040579
HScode:29322090
Characteristics-
PSA:
38.83000
XLogP3:2.76200
Appearance:White to pale yellow crystalline powder
Density:1.1±0.1 g/cm3
Melting Point:115-116 °C
Boiling Point:394.1±42.0 °C at 760 mmHg
Flash Point:166.3±22.5 °C
Refractive Index:1.533
Storage Conditions:2-8ºC
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H341 Suspected of causing genetic defects
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Ectoine sodium salt monohydrate Ectoine sodium sa
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Payment Terms:
D/P,L/C
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Average lead Time:
60
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Total Annual Revenue:
Less than $1 million
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Year of Establishment:
2008
Nanjing Chunqiu Biological Engineering Co., Ltd. has a research and development team composed of experienced natural product chemists and plant taxonomists. It is a high-tech private enterprise specializing in the extraction, development, production and sales of natural plant ingredients, focusing on functional health care. R&D and production of food raw materials, functional cosmetic raw materials, and natural medicine intermediates.
The company has R&D department, factory, sales department and other departments. The R&D department and sales department are located in Nanjing, Jiangsu, and have its own chemical research and development laboratory. The R&D department specializes in technological innovation, technology introduction, new product research and development, market research, strategic cooperation, and industrialized operation of enterprises. The sales department is located in the Jinling Biomedical Technology Industrial Park and is responsible for collecting market information, formulating sales plans, designing marketing channels, and implementing sales business.
Weifang Huazhi Biological Technology Co., Ltd. (referred to as Huazhi Biological) is a direct factory of the company, located in Weifang, Shandong, with a modern production workshop, responsible for product processing, quality assurance and improvement, manufacturing cost control and reduction, and production efficiency Improvement and production equipment management. Huazhi Biofactory has perfect extraction, separation, refining, drying equipment and technology, has rich production experience and strict quality management system, and has successively obtained ISO9001 quality management system certification and SC food production license.
Nanjing Chunqiu Biological Engineering Co., Ltd. and Huazhi Biotechnology make full use of the unique natural medicine resources. In the past 12 years, the plant medicinal active ingredient identification, research, development and production experience, constantly strive to innovate, improve self-control standards, focus on developing more Effective and more specific plant active ingredients provide innovative products and innovative services for customers in health food, cosmetics and pharmaceutical industries.
Our products and services include:
1. Functional health food raw materials;
2. Functional cosmetic raw materials;
3. Natural medicine intermediate
We are committed to providing customers with high-quality products, high-quality services, and high competitive prices.
Our business philosophy: product quality is the life of the enterprise.
Our aim: customer first, quality first, reputation first.
Our goal: strive to become an excellent team for the research and development of natural compounds of plant origin.
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